Biochemical study on the effect of Aloe vera (Latex and Leaf) as a dietary supplement on rats exposed to gamma radiation and/or aluminum
Rehab Magdy Sayed Khalifa;
Abstract
Exposure to environmental pollution from ionizing radiation as well as aluminum had been connected with the manifestation of neurodegenerative changes after long-term exposure.
Aloe vera (barbadensis) was shown to possess anti-tumor activity, anti-inflammatory, anti-bacterial, anti-diabetic, anti-microbial and antioxidant properties.
The objective of the present study is to elucidate the neurotoxic potentials of exposure to aluminum and/or -radiation induces oxidative stress and neurotransmitter alterations in rat’s brain tissue. In addition, the role of Aloe vera in modulating the severity of biochemical and histological changes that occur in the brain of irradiated and aluminum exposed rats.
Adult male albino rats Sprague Dawley (100 ± 10 g), were used as experimental animals. Aloe vera was dissolved in distilled water and administered via gavages, to rats at doses of 200 mg/Kg body weight/day. Aloe vera was freshly prepared just before its daily administration.
Experimental animals (144) were divided into eight groups (18 rats each) as follows:
Group I (Control group): rats received distilled water via gavages daily for a period of 4 weeks.
Group II (Aloe vera group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) via gavages for a period of 4 weeks.
Group III (Ir group): rats were whole body -irradiated with 8 Gy administered in four fractions of 2 Gy once a week during 4 weeks.
Group IV (Aloe vera+Ir group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) via gavages for a period of 4 weeks. On the 7th day of every week one hour post Aloe vera treatment rats were whole body -irradiated with 2 Gy once a week during four weeks .
Group V (Al group): rats received Al2(SO4)3 (0.2 mg/Kg b.w/day) via gavages for a period of 4 weeks.
Group VI (Aloe vera+Al group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) one hour before the administration of Al2(SO4)3 (0.2 mg/Kg b.w/day) for a period of 4 weeks.
Aloe vera (barbadensis) was shown to possess anti-tumor activity, anti-inflammatory, anti-bacterial, anti-diabetic, anti-microbial and antioxidant properties.
The objective of the present study is to elucidate the neurotoxic potentials of exposure to aluminum and/or -radiation induces oxidative stress and neurotransmitter alterations in rat’s brain tissue. In addition, the role of Aloe vera in modulating the severity of biochemical and histological changes that occur in the brain of irradiated and aluminum exposed rats.
Adult male albino rats Sprague Dawley (100 ± 10 g), were used as experimental animals. Aloe vera was dissolved in distilled water and administered via gavages, to rats at doses of 200 mg/Kg body weight/day. Aloe vera was freshly prepared just before its daily administration.
Experimental animals (144) were divided into eight groups (18 rats each) as follows:
Group I (Control group): rats received distilled water via gavages daily for a period of 4 weeks.
Group II (Aloe vera group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) via gavages for a period of 4 weeks.
Group III (Ir group): rats were whole body -irradiated with 8 Gy administered in four fractions of 2 Gy once a week during 4 weeks.
Group IV (Aloe vera+Ir group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) via gavages for a period of 4 weeks. On the 7th day of every week one hour post Aloe vera treatment rats were whole body -irradiated with 2 Gy once a week during four weeks .
Group V (Al group): rats received Al2(SO4)3 (0.2 mg/Kg b.w/day) via gavages for a period of 4 weeks.
Group VI (Aloe vera+Al group): rats received Aloe vera gel powder (200 mg/Kg b.w/day) one hour before the administration of Al2(SO4)3 (0.2 mg/Kg b.w/day) for a period of 4 weeks.
Other data
| Title | Biochemical study on the effect of Aloe vera (Latex and Leaf) as a dietary supplement on rats exposed to gamma radiation and/or aluminum | Other Titles | دراسة كيميائية حيوية على تأثير الصبار (الأوراق والعصارة) كمكمل غذائى علي الجرذان المعرضة للإشعاع الجامى و/ أو الألومنيوم | Authors | Rehab Magdy Sayed Khalifa | Issue Date | 2016 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| G13116.pdf | 316.97 kB | Adobe PDF | View/Open |
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