Prophylactic Use of Intraumbilical Vein Oxytocin in the Management of Third Stage of Labor A Randomized Controlled trial CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01094028.
May Mohamed Ahmad Shafeek;
Abstract
The third stage is the interval between delivery of the infant and delivery of the placenta. This stage averages 10 minutes and is considered prolonged if it lasts longer than 30 minutes, placental separation occurs as a result of continued uterine contractions, continued contractions control blood loss by compression of spiral arteries and also result in migration of the placenta into the lower uterine segment and then through the cervix.
The intra-umbilical vein injection of 10 IU of oxytocin is recommended as a first line of treatment for unseparated placenta. Despite this recommendation, the method has yet to make its way into routine practice, probably because of the lack of a large substantive randomized controlled trial, and lingering doubts over which uterotonic to use and at what dosage.
The aim of the present study was to evaluate the effect of intra-umbilical vein injection of oxytocin on reducing the duration of the third stage of labour and the need for manual delivery of placenta; in comparison with normal saline administration.
This is prospective randomized control trial .This study included 150 term pregnant women in labour admitted to the labour ward, They were divided into 2 groups:
Group I (75 women) (study group) In whom 10 IU of oxytocin intra-umbilical vein was injected into the umbilical vein at the most proximal site to the placenta after clamping and cutting of the umbilical cord.
Group II (75 women) in whom 1 mL normal saline was injected into the umbilical vein at the most proximal site to the placenta after clamping and cutting of the umbilical cord.
There was no statistically significant difference between the two groups concerning age and parity.
This study revealed that there were no statistically significant differences between the two groups concerning hemoglobin level and duration of 3rd stage of labor, rate of postpartum hemorrhage , rate of need of manual separation of the placenta and blood loss during the third stage of labour .
The intra-umbilical vein injection of 10 IU of oxytocin is recommended as a first line of treatment for unseparated placenta. Despite this recommendation, the method has yet to make its way into routine practice, probably because of the lack of a large substantive randomized controlled trial, and lingering doubts over which uterotonic to use and at what dosage.
The aim of the present study was to evaluate the effect of intra-umbilical vein injection of oxytocin on reducing the duration of the third stage of labour and the need for manual delivery of placenta; in comparison with normal saline administration.
This is prospective randomized control trial .This study included 150 term pregnant women in labour admitted to the labour ward, They were divided into 2 groups:
Group I (75 women) (study group) In whom 10 IU of oxytocin intra-umbilical vein was injected into the umbilical vein at the most proximal site to the placenta after clamping and cutting of the umbilical cord.
Group II (75 women) in whom 1 mL normal saline was injected into the umbilical vein at the most proximal site to the placenta after clamping and cutting of the umbilical cord.
There was no statistically significant difference between the two groups concerning age and parity.
This study revealed that there were no statistically significant differences between the two groups concerning hemoglobin level and duration of 3rd stage of labor, rate of postpartum hemorrhage , rate of need of manual separation of the placenta and blood loss during the third stage of labour .
Other data
| Title | Prophylactic Use of Intraumbilical Vein Oxytocin in the Management of Third Stage of Labor A Randomized Controlled trial CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01094028. | Other Titles | دراسة عشوائية في الاستخدام الوقائي للأوكسيتوسين بحقنه داخل الوريد السري في إدارة المرحلة الثالثة عند الولادة | Authors | May Mohamed Ahmad Shafeek | Issue Date | 2017 |
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