STUDY OF THE IMPACT OF CARDIOPULMONARY BYPASS ON THE LIVER IN PATIENTS WITH CONGENITAL HEART DISEASES

Abstract

Extracorporeal circulation enables surgeons to treat a wide range of heart diseases while circulation and oxygenation of human blood are maintained by machines. While the first successful CBP during a ventricular septum repair in 1953 by Gibbon was still an experimental procedure, CPB has in the meantime emerged as a well-established procedure used worldwide. CPB-induced inflammatory responses are associated with dysfunction of multiple organs, including the heart, lungs, kidneys, and liver, and the coagulation system. This dysfunction may subsequently result in series of severe complications, some of which have high overall Mortalities. It is therefore necessary to identify an effective means of inhibiting CPB-induced inflammatory responses at an early stage. The current study included 23 (57.5%) males and 17 (42.5%) females, their age ranged between 5 and 144 days with mean of 30.70±29.47, their weight ranged between 4.50 and 28Kg with mean of 10.90±4.71Kg, there are 28(70%) with +ve consanguinity and 12 (30%) with –ve consanguinity, and 25 (62.5%) with +ve family history and 15 (37.5%) with –ve family history.