The Effect of Mulberry Leaves on Hyperglycemia and Hyperlipidemia
Yara Ibrahim Mohammed;
Abstract
SUMMARY
D
iabetes mellitus is a worldwide major health problem with approximately 5% of the world’s population suffering from the disease. It is a disease caused by reduced insulin production or impaired insulin response in target organs. It is characterized by high blood glucose levels, abnormal metabolism of carbohydrates, proteins and fat. Such alterations causes long-term complications in many organs. The effective control of blood glucose is the key in preventing or reversing diabetic complications and improving the quality of life for both type I and type II diabetic patients. Although different types of oral hypoglycemic agents are available along with insulin for the treatment of DM none offers complete glycemic control.
Traditional plant medicines are used throughout the world for a range of diabetic presentations. Therefore, an investigation of such agents from traditional medicinal plants has become particularly important. One of the known traditional medicinal plants is mulberry. Mulberry is a tree belonging to the genus Morus of the family Moraceae. MBL are a known traditional medicine for preventing DM, its anti-diabetic effect was contributed to α-glucosidase inhibitory activity thus acting as a preventive and therapeutic agent for type 2 DM and its complication. The present study aimed to study and evaluate the therapeutic efficacy of MBL in diabetic animal model.
The results have shown that:
1) Mulberry leaves including both FMBL and DMBL have successfully reduced blood glucose level in STZ injected rats
2) Mulberry leaves including both FMBL and DMBL have shown a positive effect on diabetic dyslipedemia by decreasing the increased level of LDL, TAG, TC and increasing the decreased level of HDL in STZ injected rats.
3) Mulberry leaves including both FMBL and DMBL have affected the oxidative stress resulted from diabetic complication by decreasing the increased level of GSH-Px, SOD antioxidants and also decreasing the increased level of lipid peroxidation product (MDA).
D
iabetes mellitus is a worldwide major health problem with approximately 5% of the world’s population suffering from the disease. It is a disease caused by reduced insulin production or impaired insulin response in target organs. It is characterized by high blood glucose levels, abnormal metabolism of carbohydrates, proteins and fat. Such alterations causes long-term complications in many organs. The effective control of blood glucose is the key in preventing or reversing diabetic complications and improving the quality of life for both type I and type II diabetic patients. Although different types of oral hypoglycemic agents are available along with insulin for the treatment of DM none offers complete glycemic control.
Traditional plant medicines are used throughout the world for a range of diabetic presentations. Therefore, an investigation of such agents from traditional medicinal plants has become particularly important. One of the known traditional medicinal plants is mulberry. Mulberry is a tree belonging to the genus Morus of the family Moraceae. MBL are a known traditional medicine for preventing DM, its anti-diabetic effect was contributed to α-glucosidase inhibitory activity thus acting as a preventive and therapeutic agent for type 2 DM and its complication. The present study aimed to study and evaluate the therapeutic efficacy of MBL in diabetic animal model.
The results have shown that:
1) Mulberry leaves including both FMBL and DMBL have successfully reduced blood glucose level in STZ injected rats
2) Mulberry leaves including both FMBL and DMBL have shown a positive effect on diabetic dyslipedemia by decreasing the increased level of LDL, TAG, TC and increasing the decreased level of HDL in STZ injected rats.
3) Mulberry leaves including both FMBL and DMBL have affected the oxidative stress resulted from diabetic complication by decreasing the increased level of GSH-Px, SOD antioxidants and also decreasing the increased level of lipid peroxidation product (MDA).
Other data
| Title | The Effect of Mulberry Leaves on Hyperglycemia and Hyperlipidemia | Other Titles | تقييم تأثير ورق شجر التوت على إرتفاع السكر و الدهنيات بالدم | Authors | Yara Ibrahim Mohammed | Issue Date | 2016 |
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