Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion Randomized Controlled Trial

Abstract

he need for termination of pregnancy in the second trimester has significantly increased due to the wide scale introduction of prenatal screening programs. Women whose pregnancies are associated with medical disorders or associated with serious fetal anomalies, termination might be a must. Misoprostol (Cytotec) is synthetic prostaglandin E, and is currently available as a 200-μg tablet for prevention of peptic ulcers. It has been used "off label" for preinduction cervical ripening and labor induction. Nitric oxide releasing drugs are a novel class of effective and safe agents for cervical ripening. Several studies have shown the promising role of nitric oxide donors in obstetrics. They are cheap and have a good safety profile. Our research aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester missed abortion . Our study included 60 women with gestational age between 13weeks+0day and 26weeks+6days indicated for pregnancy termination due to maternal or fetal cause.