Pathological Role of Biofilm in Fungal Rhinosinusitis

Abstract

The first case of fungal sinusitis was reported in 1885. This fungal disease occurred rarely until the past decade, when a worldwide increase in its incidence occurred (Lund et al., 2000). Till one decade back bacteria was implicated as pathogen in most form of chronic rhinosinusitis (CRS). Fungi were thought to be responsible for few specific forms, since 1999, when Ponikau and associates claimed that fungi were responsible for nearly all cases of CRS. Their Study demonstrated the presence of fungi & eosinophils from nose & paranasal sinuses from ~100% cases of CRS (Ponikau et al., 1999).