Relationship of Serum Uric Acid Level and Angiographic Severity of Coronary Artery Disease in Patients with non ST Segment Elevation Acute Coronary Syndrome

Abstract

SUMMARY D espite all the recent progress and breakthroughs, CVD, mainly CAD are still the leading cause of mortality worldwide. CV risk factors can crudely be classified into non-modifiable and modifiable risk factors, the first group are the risk factors that can’t be changed, namely age, gender, ethnic group and family history. The modifiable risk factors are the target for preventive cardiology, since this is where you can really make a difference and save lives. Since the beginning of the 20th century, serum UA has been suggested as a CV risk factor, and numerous studies were conducted to determine its actual relationship to CAD, which is still in fact a matter of debate. Some studies have shown that the association between serum UA and CAD remains significant even after adjustment for concomitant risk factors, suggesting that serum UA is an independent risk factor for CAD. Other studies even failed to show any association between CAD and UA at all. Our study aimed at assessing whether serum UA is an independent risk factor for severity of CAD. The study included 100 patients presented with NSTEMI and UA and underwent coronary angiography, at Ain Shams university hospitals from July 2016 to February 2017. The study population was subjected to full history taking, physical examination, 12-lead ECG, echocardiography, laboratory investigations including serum UA levels, and coronary angiography, SYNTAX and Gensini scores calculated to all patients to assess the severity of CAD. The study results showed that serum UA and was not significantly correlated with severity of CAD, numbers of coronary vessels affected, percent luminal narrowing or sites of significant lesions.