BIOLOGICAL EVALUATION FOR SOME PLANTS USED FOR TREATEMNT OF DIABETES AND HYPERLIPIDAEMICS

Abstract

Diabetes can affect many different organ systems in the body and over time can lead to serious complications. This study aimed to decrease sugar concentration in blood and hyperlipidemia using dryCinnamon and Amlafruits. Male albino rats Spargue DawleyStrain (66-rats) weighing (200 ± 10 g) were divided into three main groups as follows: The first main group (1) (6 rats) was fed on basal diet (as a control negative group). The second main group (30 rats) normal rats fed on standard diet contained 10% saturated fat to induce hyperlipidemic, then rats in the third main group were divided into 5subgroups: Subgroup (1): hyperlipdemic rats fed on basal diet (positive control group). Subgroup (2): fed on high fat diet containing 1% Cinnamon and 1.5% Cinnamon and Amla. The third group (30 rats) the rats were injected with alloxan (120 mg / kg body weight) to induce diabetes. Then rats were divided into 5subgroups: Subgroup :diabetic fed on basal diet as positive control group. Other subgroup: fed on basal diet containing 1% Cinnamon and 1.5% Cinnamon and Amla. After 4 weeks the effect of the different experimental diets on glucose, glycoulated, liver and kidney function and blood lipid profile were determined. It could be concluded that, feeding on Cinnamon and Amla fruits led to significant decrease in glucose level and blood lipids of positive group rats compared with diabetic and hyperlipidemia rats fed on basal diet. Thereduction of glucose and blood lipids were observed after one week of feeding till the end of experimental period. Also, the animals had significantly lower in total cholesterol, triglyceride and total lipids in comparing to positive diabetic and hyperlipidemia rats fed on control.