Serum-Soluble Fas Antigen in Patients with Lymphoid Malignancies
Rehab Saleh El Hagrasy;
Abstract
Fas antigen plays an integral role in the regulation of
1mmune system functions, removal of autoactivated lymphocytes, viral infected cells and malignant cells. Fas antigen presents in two forms: membrane bound form that initiates apoptosis of target cells after binding its ligand that presents on target cell membrane, and sFas form that inhibits apoptosis through neutralizing Fas-L on target cell. Therefore, disturbance in Fas/Fas-L function contributes to the development, growth, expansion of tumors, and their resistance to therapy.
Lymphoid malignancies incidence was increased in the last few years with progressive increase in their incidence with time, together with the concurrent increase in rate of deaths.
The aim of the study was to study the serum sFas level m patients with different lymphoid malignancies including non-Hodgkin's lymphoma, Hodgkin's disease, acute lymphoblastic leukemia and chronic lymphocytic leukemia and its relation to the disease status in comparison to healthy control subjects.
Our study was carried out on 65 subjects divided into 15 healthy control and 50 patients with different lymphoid malignancies.
1mmune system functions, removal of autoactivated lymphocytes, viral infected cells and malignant cells. Fas antigen presents in two forms: membrane bound form that initiates apoptosis of target cells after binding its ligand that presents on target cell membrane, and sFas form that inhibits apoptosis through neutralizing Fas-L on target cell. Therefore, disturbance in Fas/Fas-L function contributes to the development, growth, expansion of tumors, and their resistance to therapy.
Lymphoid malignancies incidence was increased in the last few years with progressive increase in their incidence with time, together with the concurrent increase in rate of deaths.
The aim of the study was to study the serum sFas level m patients with different lymphoid malignancies including non-Hodgkin's lymphoma, Hodgkin's disease, acute lymphoblastic leukemia and chronic lymphocytic leukemia and its relation to the disease status in comparison to healthy control subjects.
Our study was carried out on 65 subjects divided into 15 healthy control and 50 patients with different lymphoid malignancies.
Other data
| Title | Serum-Soluble Fas Antigen in Patients with Lymphoid Malignancies | Other Titles | دراسة ف أ س الذائب فى مصل الدم لدى مرضى الاورام اللفاوية الخبيثة | Authors | Rehab Saleh El Hagrasy | Issue Date | 2001 |
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