Effect of Fosinopril on some constituents in Experimentally induced Diabetes Mellitus in Rats

Abstract

Diabetes mellitus is a major health care issue. Insulin dependent diabetes (IDDM) and non-insulin dependent diabetes (NIDDM) affect 2- 4% of the population, while in some subgroup of the population the prevalence ofNIDDM approaches 25%.

Diabetes mellitus is not only common but also has significant impact on the morbidity and mortality of the people who suffer from the disease. Macrovascular disease is a major problem in patients with diabetes mellitus. Patients with type I and type II diabetes mellitus have an increased risk of coronary heart disease.

Elevated levels of total cholesterol (total-c), low density lipoprotein cholesterol (LDL-c) . and apolipoprotein B promote human atherosclerosis. Similarly, decreased levels of high density lipoprotein cholesterol (HDL-c) and its transport complex, apolipoprotein A, are associated with the development of atherosclerosis.

In diabetes, dyslipidemia consists of fi.y.pertrigl demia•.•with raised VLDL, total cholesterol and LDL.

Aside from lowering elevated blood pressure, therapy with antihypertensive agents may result in a vast variety of metabolic actions.