Preparation of Some Radiolabeled Pharmaceutical Compounds of Expected Biological Activity
Marwa Eid Sayyed Farrag;
Abstract
Preparation of some radiolabeled pharmaceutical compounds
of expected biological activity
The human brain is the command center for the human nervous system. It receives input from the sensory organs and sends output to the muscles. There are many several receptors on the brain receptors that have a prominent role in brain function, as they are the effector sites of neurotransmission at the postsynaptic membrane, have a regulatory role on presynaptic sites for transmitter reuptake and feedback and are modulating various functions on the cell membrane. Distribution, density and activity of receptors in the brain can be visualized by radioligands labeled for SPECT and PET. Selective radioligands are available for the various transmitter systems by which the distribution of these receptors in the normal brain and changes in receptor binding during various physiologic activities or resulting from pathologic conditions can be visualized.
The aim of this thesis is to develop potential selective radiopharmaceuticals for the non-invasive brain imaging. The selection of the proper isotope to be used in labeling and in imaging is important because it should have a suitable short half-life to avoid unwarranted harmful exposure to radiation and suitable photon energy within the range of gamma camera. The measurement of regional cerebral blood flow (rCBF) by single-photon emission computed tomography (SPECT) represents the most commonly available and widely applied functional brain imaging technique used in clinical practice. Several recent reviews describe the use of SPECT alone or in combination with PET and/or functional magnetic resonance imaging (fMRI) in studies of human cognition, imaging of neuroreceptor systems, in aiding diagnosis or assessment of progression or treatment response in various psychiatric and neurologic disorders. Brain SPECT is now commonly used in diagnosis, prognosis assessment, evaluation of response to therapy, risk stratification, detection of benign or malignant viable tissue and choice of medical or surgical therapy, especially in head injury, malignant brain tumors, cerebrovascular disease, movement disorders, dementia and epilepsy.
of expected biological activity
The human brain is the command center for the human nervous system. It receives input from the sensory organs and sends output to the muscles. There are many several receptors on the brain receptors that have a prominent role in brain function, as they are the effector sites of neurotransmission at the postsynaptic membrane, have a regulatory role on presynaptic sites for transmitter reuptake and feedback and are modulating various functions on the cell membrane. Distribution, density and activity of receptors in the brain can be visualized by radioligands labeled for SPECT and PET. Selective radioligands are available for the various transmitter systems by which the distribution of these receptors in the normal brain and changes in receptor binding during various physiologic activities or resulting from pathologic conditions can be visualized.
The aim of this thesis is to develop potential selective radiopharmaceuticals for the non-invasive brain imaging. The selection of the proper isotope to be used in labeling and in imaging is important because it should have a suitable short half-life to avoid unwarranted harmful exposure to radiation and suitable photon energy within the range of gamma camera. The measurement of regional cerebral blood flow (rCBF) by single-photon emission computed tomography (SPECT) represents the most commonly available and widely applied functional brain imaging technique used in clinical practice. Several recent reviews describe the use of SPECT alone or in combination with PET and/or functional magnetic resonance imaging (fMRI) in studies of human cognition, imaging of neuroreceptor systems, in aiding diagnosis or assessment of progression or treatment response in various psychiatric and neurologic disorders. Brain SPECT is now commonly used in diagnosis, prognosis assessment, evaluation of response to therapy, risk stratification, detection of benign or malignant viable tissue and choice of medical or surgical therapy, especially in head injury, malignant brain tumors, cerebrovascular disease, movement disorders, dementia and epilepsy.
Other data
| Title | Preparation of Some Radiolabeled Pharmaceutical Compounds of Expected Biological Activity | Other Titles | تحضير بعض المركبات الصيدلانية المشعة المتوقع لها نشاط بيولوجي | Authors | Marwa Eid Sayyed Farrag | Issue Date | 2017 |
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