Oxidative stress markers and antioxidant level in neonatal hyperbilirubinemia
Nesrine Salah El-Din Ahdel Hamid;
Abstract
Hyperbilirubinemia continues to be a common problem of the term and near term neonate. Each year more than 60 % of infants develop jaundice, making it difficult at times to differentiate jaundice due to physiological reasons from jaundice due to pathological ones.
Oxygen free radicals are highly reactive, they can de!laturate proteins, DNA, and initiate lipid peroxidation. They are implicated in many disease processes, including pulmonary oxygen injury, intraventircular hemorrhage, retinopathy of prematurity and others. Free radical •reactions provide a product of lipid peroxidation i.e Malondialdehyde. Antioxidants such as SOD, act as a defense system against oxidative stress.
Inspite of its potential toxicity, bilirubin may have an important and positive physiological role. In early neonatal life bilirubin may play a role in preventing oxidative membrane damage. Jaundice is not simply an accumulation of a potentially toxic waste product in need of excretion, but it may serve a beneficial role by providing a high concentration of a free radical absorbing antioxidant now the knowledge that bilirubin may even have a beneficial role as an antioxidant has caused a great deal of renewed interest in the management of jaundice.
Oxygen free radicals are highly reactive, they can de!laturate proteins, DNA, and initiate lipid peroxidation. They are implicated in many disease processes, including pulmonary oxygen injury, intraventircular hemorrhage, retinopathy of prematurity and others. Free radical •reactions provide a product of lipid peroxidation i.e Malondialdehyde. Antioxidants such as SOD, act as a defense system against oxidative stress.
Inspite of its potential toxicity, bilirubin may have an important and positive physiological role. In early neonatal life bilirubin may play a role in preventing oxidative membrane damage. Jaundice is not simply an accumulation of a potentially toxic waste product in need of excretion, but it may serve a beneficial role by providing a high concentration of a free radical absorbing antioxidant now the knowledge that bilirubin may even have a beneficial role as an antioxidant has caused a great deal of renewed interest in the management of jaundice.
Other data
| Title | Oxidative stress markers and antioxidant level in neonatal hyperbilirubinemia | Other Titles | دلالات ضغوط الاكسدة ومضادات الاكسدة فى حالات اليرقان الوليدى | Authors | Nesrine Salah El-Din Ahdel Hamid | Issue Date | 2001 |
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