A Prospective Cohort Study to Assess Soluble FAS Ligand as a Marker of Fetal Programming and an Early Predictor of Feto-Maternal Sensitization in Relation to In Vivo IgE Assessment and Peripheral Blood Mononuclear Cells
Doha Magdy Mohamed Emam;
Abstract
SUMMARY
A
llergy is a state of sensitization of the immune system, a disease mechanism, rather than a specific disease entity. Programming of disease in fetal and early postnatal life has been hypothesized to be an important mechanism for atopic diseases.
Peripheral blood mononuclear cell responses to allergen can be detected from as early as 22 weeks gestation. This suggests that fetal life is a critical period for development of atopic diseases and may be an important “window of opportunity” for prevention of disease.
Many immune cells express Fas (CD95) on their surface), Fas Ligand is a type II trans-membrane protein that belongs to the tumor necrosis factor (TNF) family.
S.Fas Ligand has been correlated to allergic diseases in several studies as atopic dermatitis, asthmatic and allergic rhinitis in children.
Our prospective cohort study was designed to assess soluble Fas Ligand as a marker of fetal program
A
llergy is a state of sensitization of the immune system, a disease mechanism, rather than a specific disease entity. Programming of disease in fetal and early postnatal life has been hypothesized to be an important mechanism for atopic diseases.
Peripheral blood mononuclear cell responses to allergen can be detected from as early as 22 weeks gestation. This suggests that fetal life is a critical period for development of atopic diseases and may be an important “window of opportunity” for prevention of disease.
Many immune cells express Fas (CD95) on their surface), Fas Ligand is a type II trans-membrane protein that belongs to the tumor necrosis factor (TNF) family.
S.Fas Ligand has been correlated to allergic diseases in several studies as atopic dermatitis, asthmatic and allergic rhinitis in children.
Our prospective cohort study was designed to assess soluble Fas Ligand as a marker of fetal program
Other data
| Title | A Prospective Cohort Study to Assess Soluble FAS Ligand as a Marker of Fetal Programming and an Early Predictor of Feto-Maternal Sensitization in Relation to In Vivo IgE Assessment and Peripheral Blood Mononuclear Cells | Other Titles | دراسة مستقبلية لفحص مرابط الفاس الذائب كمؤشر لبرمجة الجنين و للتنبؤ المبكر لأمراض الحساسية في الأطفال و علاقة التحسس الجنيني للأم و مطابقة ذلك باختبار الحساسية بالجلد و خلايا الدم أحادية النواة | Authors | Doha Magdy Mohamed Emam | Issue Date | 2017 |
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