A pharmaceutical Study on Some Sustained Release Solid Dosage Forms Containing Tiaprofenic Acid

Abstract

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used in the treatment of various musculo-skeletal disorders and painful conditions. The drug has proven therapeutic efficacy, tolerability and safety. The short plasma half-life, 1 - 2 hours, following oral dosing necessitates a three-time a day administration of the drug to maintain peak and trough concentrations within the therapeutic range. Patient compliance is known to be fairly poor with such frequent dosing regimen. Furthermore, the conventional dosage forms do not provide protection against the side effects associated with non-steroidal anti-inflammatory drugs such as the irritation of the gastrointestinal mucosa. Thus clinical benefit and related advantages are likely if such a drug were to be administered as a modified release dosage form. A multiple-unit system was proposed here in view of the many advantages that those dosage forms offer. Accordingly, the work in this thesis is divided into three parts, namely, preparation and evaluation of tiaprofenic acid-cellulose acetate butyrate microcapsules, preparation and evaluation of tiaprofenic acid microcapsules using natural polymers, and pharmacodynamic activity oftiaprofenic acid from various microcapsule preparations.