LEPTIN in UMBILICAL CORD BLOOD of FULL TERM NEONATES in RELATION to THEIR ANTHROPOMETRIES
Engy Emil Hanna;
Abstract
Birth weight remains one of the most important measures of the health status of a population, and is a strong predictor of both neonatal mortality and morbidity. It can reflect fetal growth rates in the antenatal period. Leptin is an emerging important hormone, produced by adipose tissue, placenta, ovaries, mammary epithelium, bone marrow, and lymphoid tissues, and its function is to control energy homestasis and body weight.
Our prospective comparative study conducted to investigate the relationship between venous umbilical cord serum leptin and anthropometric measurements at birth in 40 healthy full term neonates of the three different weight for gestational age groups (LGA, SGA and AGA). We also analyzed the gender differences between leptin levels and the anthropometric markers at birth. Then we followed up them at age of 1 month to compare those anthropometric markers with initial measurements at birth. Regarding gender distribution, there was 18 males and 22 females, and according to their gestational age they were classified to 7 LGA, 7 SGA and 26 AGA.
Girls showed statistically significant higher mean cord serum leptin levels than boys.
There was a highly statistically significant difference between all GA groups as regard serum leptin in cord blood. LGA showed the statistically significant highest mean umbilical cord serum leptin level. This was followed by babies classified as AGA then SGA who showed the statistically significant lowest mean serum cord leptin level. This difference between leptin levels in LGA, AGA and SGA may be because of linear relationship between fetal growth and/or adiposity and fetal leptin levels.
Also, there was a significant positive correlation between serum cord leptin level and birth weight, length, birth weight/birth length, head circumference, Ponderal index and BMI in newborns, suggesting an association with neonatal growth.
There was a statistically significant difference between all GA groups as regard maternal BMI, as well as, there was a statistically significant correlation between maternal BMI and serum leptin and all anthropometries at birth in all GA groups.
There was a highly statistically significant difference between cord leptin level on one hand and all anthropometric measurements at 1 month of age on the other hand.
Also, there was a highly statistical significant difference between at birth and at one month as regard rate of change in serum leptin and BW between LGA and SGA groups. the low leptin levels in cord blood strongly predicated high rates of weight gain in infancy and catch up growth. The fall in leptin level might be an important stimulation for feeding behavior and energy uptake and be necessary for rapid neonatal growth.
On the other hand, there was a positive correlation between serum leptin and all anthropometric measurements at one month in LGA and SGA groups.
Finally, there was a significant higher serum leptin levels in breast fed (BF) infants than in formula fed (FF) infants.
Our prospective comparative study conducted to investigate the relationship between venous umbilical cord serum leptin and anthropometric measurements at birth in 40 healthy full term neonates of the three different weight for gestational age groups (LGA, SGA and AGA). We also analyzed the gender differences between leptin levels and the anthropometric markers at birth. Then we followed up them at age of 1 month to compare those anthropometric markers with initial measurements at birth. Regarding gender distribution, there was 18 males and 22 females, and according to their gestational age they were classified to 7 LGA, 7 SGA and 26 AGA.
Girls showed statistically significant higher mean cord serum leptin levels than boys.
There was a highly statistically significant difference between all GA groups as regard serum leptin in cord blood. LGA showed the statistically significant highest mean umbilical cord serum leptin level. This was followed by babies classified as AGA then SGA who showed the statistically significant lowest mean serum cord leptin level. This difference between leptin levels in LGA, AGA and SGA may be because of linear relationship between fetal growth and/or adiposity and fetal leptin levels.
Also, there was a significant positive correlation between serum cord leptin level and birth weight, length, birth weight/birth length, head circumference, Ponderal index and BMI in newborns, suggesting an association with neonatal growth.
There was a statistically significant difference between all GA groups as regard maternal BMI, as well as, there was a statistically significant correlation between maternal BMI and serum leptin and all anthropometries at birth in all GA groups.
There was a highly statistically significant difference between cord leptin level on one hand and all anthropometric measurements at 1 month of age on the other hand.
Also, there was a highly statistical significant difference between at birth and at one month as regard rate of change in serum leptin and BW between LGA and SGA groups. the low leptin levels in cord blood strongly predicated high rates of weight gain in infancy and catch up growth. The fall in leptin level might be an important stimulation for feeding behavior and energy uptake and be necessary for rapid neonatal growth.
On the other hand, there was a positive correlation between serum leptin and all anthropometric measurements at one month in LGA and SGA groups.
Finally, there was a significant higher serum leptin levels in breast fed (BF) infants than in formula fed (FF) infants.
Other data
| Title | LEPTIN in UMBILICAL CORD BLOOD of FULL TERM NEONATES in RELATION to THEIR ANTHROPOMETRIES | Other Titles | نسبة اللبتين في الحبل السري للمواليد كاملة النمووعلاقته بنسبهم الانثروبومترية | Authors | Engy Emil Hanna | Issue Date | 2015 |
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