COMPARISON BETWEEN THE EFFECT OF HYPERBARIC AND NORMOBARIC HYPEROXIA ON THE FUNCTIONAL OUTCOME IN PATIENTS WITH TRAUMATIC BRAIN INJURY
Mohammed Hamdy Abd El-hamid Harb;
Abstract
Traumatic brain injury (TBI) continues to be a major cause of death and disability in both civilian and military populations throughout the world (Maas et al., 2007).
In Egypt, road traffic accidents is the leading cause of TBI,
70% of accidents are due to ignorance and carelessness, and 30% are the result of mechanical problems and poor road conditions. These include insufficient pedestrian crossing facilities and deficient traffic signs at intersections. The situation in Egypt is serious and getting worse year by year, especially exacerbated by the progressing density of traffic, with an annual increase of
80,000 vehicles (El-Gindi et al., 2001).
The first stages of cerebral injury after TBI are characterized by direct tissue damage and impaired regulation of cerebral blood flow and metabolism. This ischemic pattern leads to accumulation of lactic acid due to anaerobic glycolysis, increased membrane permeability, consecutive edema formation and this anaerobic metabolism is inadequate to maintain cellular energy states (Werner and Engelhard, 2007).
In Egypt, road traffic accidents is the leading cause of TBI,
70% of accidents are due to ignorance and carelessness, and 30% are the result of mechanical problems and poor road conditions. These include insufficient pedestrian crossing facilities and deficient traffic signs at intersections. The situation in Egypt is serious and getting worse year by year, especially exacerbated by the progressing density of traffic, with an annual increase of
80,000 vehicles (El-Gindi et al., 2001).
The first stages of cerebral injury after TBI are characterized by direct tissue damage and impaired regulation of cerebral blood flow and metabolism. This ischemic pattern leads to accumulation of lactic acid due to anaerobic glycolysis, increased membrane permeability, consecutive edema formation and this anaerobic metabolism is inadequate to maintain cellular energy states (Werner and Engelhard, 2007).
Other data
| Title | COMPARISON BETWEEN THE EFFECT OF HYPERBARIC AND NORMOBARIC HYPEROXIA ON THE FUNCTIONAL OUTCOME IN PATIENTS WITH TRAUMATIC BRAIN INJURY | Authors | Mohammed Hamdy Abd El-hamid Harb | Issue Date | 2018 |
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