Study of Glutathione Peroxidase • and Selenium Levels in Newborns • . with Jaundice
Eman Salah El Den Abdel Rahman;
Abstract
Neonatal jaundice is one of the common problems confronting pediatricians.
Newborns are subject to increased oxidative stress, and in cases where there is a depressed antioxidant system, i.e, lower glutathione peroxidase activity and lower selenium levels, the reactive oxygen intermediates formed in the erythrocytes may attack their membrane, leading to jaundice.
The present study was aimed to study the levels of blood glutathione peroxidase enzyme and serum selenium in neonates with hyperbilirubinemia as indicators of antioxidative metabolism. It was conducted in Neonatal Intensive Care Unit of Obstetrics and Gynecology Hospital, Ain Shams University. It included 30 neonates with indirect hyperbilimbinemia (17: males and 13 females) whose ages ranged between 1 to 12 days (mean age 4:!;:2.7) and 11 •age and sex matched healthy neonates as controls.
The patient were divided into 2 groups according to the cause of jatmdice into group of physiological jaundice (group 1) and group of jaundice due to sepsis (group 2). Each group was also divided into two subgroups according to the gestational age into "a" fullterm and "b" pretenn.
To all studied neonates, full history and thorough clinical examination, laboratory investigations including blood group, Rh, CBC, TLC, platelet count, total and direct bilimbin, CRP, direct Coombs' test and antioxidants including (blood gluathione, peroxidase and sennn selenium levels were done).
Newborns are subject to increased oxidative stress, and in cases where there is a depressed antioxidant system, i.e, lower glutathione peroxidase activity and lower selenium levels, the reactive oxygen intermediates formed in the erythrocytes may attack their membrane, leading to jaundice.
The present study was aimed to study the levels of blood glutathione peroxidase enzyme and serum selenium in neonates with hyperbilirubinemia as indicators of antioxidative metabolism. It was conducted in Neonatal Intensive Care Unit of Obstetrics and Gynecology Hospital, Ain Shams University. It included 30 neonates with indirect hyperbilimbinemia (17: males and 13 females) whose ages ranged between 1 to 12 days (mean age 4:!;:2.7) and 11 •age and sex matched healthy neonates as controls.
The patient were divided into 2 groups according to the cause of jatmdice into group of physiological jaundice (group 1) and group of jaundice due to sepsis (group 2). Each group was also divided into two subgroups according to the gestational age into "a" fullterm and "b" pretenn.
To all studied neonates, full history and thorough clinical examination, laboratory investigations including blood group, Rh, CBC, TLC, platelet count, total and direct bilimbin, CRP, direct Coombs' test and antioxidants including (blood gluathione, peroxidase and sennn selenium levels were done).
Other data
| Title | Study of Glutathione Peroxidase • and Selenium Levels in Newborns • . with Jaundice | Other Titles | دراسة مستوى بيروكسيداز الجلوتاثايون والسيلينيوم فى الصفراء الوليدية | Authors | Eman Salah El Den Abdel Rahman | Issue Date | 2001 |
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