Study Of The Association Between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism (677C/T) And

Abstract

Migraine is a recurrent neurovascular disorder which lowers the quality of life. Severe head pain, in addition to the symptoms of nausea and vomiting, is the most bothersome complaint of these patients. Usually, light and sound can have an effect on the severity and frequency of these symptoms. Middle-aged women are more susceptible to migraine occurrence than men. It is divided into migraine with aura or migraine without aura (Sadeghi et al., 2016). Molecular genetic studies of migraine have investigated many polymorphisms possibly associated with migraine. The most common examined gene is MTHFR gene polymorphism (Kowalska et al., 2016). MTHFR enzyme plays a key role in homocysteine metabolism and DNA methylation which is encoded by MTHFR gene. MTHFR gene polymorphism C677T reduces the enzymatic activity resulting in increased homocysteine concentrations, and reduced methylation capacity (Tsang et al., 2015). This study was conducted on 45 subjects who were divided into two groups.GroupI (patients group) which included thirty (30) adult patients with migraine recruited from headache clinic in Ain Shams University hospitals, they were diagnosed with migraine according to ICHD diagnostic criteria 3rd edition beta version (2013) and