Association of different Variable Number of Tandem Repeats in Interleukin-1 Receptor Antagonist gene (IL-1 Ra VNTRs) with susceptibility to Childhood Immune Thrombocytopenia
Omnia Mohammed Abdel Aziz Borham;
Abstract
SUMMARY
I
mmune thrombocytopenia (ITP) is an acquired autoimmune disorder and the most common cause of isolated thrombocytopenia in children. The presence of families with inherited ITP, increased frequency of ITP in some genetic syndromes, and evidence of an association between ITP and several candidate immune genes collectively point to the presence of individual genetic risks for ITP. It is generally accepted that both environmental and genetic factors are involved in the pathogenesis of ITP. IL-1 Ra polymorphisms were reported to be associated with susceptibility of a variety of autoimmune diseases.
This pilot case – control study was conducted at Hematology Oncology unit Children’s Hospital, Ain-Shams University in the period from October 2013 to January 2015, included 60 Egyptian children and adolescents from unrelated families, diagnosed with ITP who were regularly attending the clinic, aged 1-17years with mean of 9.2± 4.5. They were 37 female patients and 23 male patients. The study also included 50 age, sex and ethnically matched healthy controls.
We investigated the association between VNTRs of IL-1Ra Polymorphism and the susceptibility of ITP, The frequencies of the IL-1Ra polymorphic allele A2 as well as genotype A1A2 was significantly higher in cases of ITP compared to control.
The presence of allele A2 seems to increase 3.1 times the relative risk for disease development. Allele A1 may have a decreased risk for development of ITP. These findings suggested that IL-1Ra polymorphism may contribute to the susceptibility to ITP.
Comparison of genotypes and alleles regarding contributing factors associated with disease and demographic data were evaluated. There was no gender predominance among different genotypes. Also no significant difference was observed when the genotypes were compared regarding age of onset of the disease.
I
mmune thrombocytopenia (ITP) is an acquired autoimmune disorder and the most common cause of isolated thrombocytopenia in children. The presence of families with inherited ITP, increased frequency of ITP in some genetic syndromes, and evidence of an association between ITP and several candidate immune genes collectively point to the presence of individual genetic risks for ITP. It is generally accepted that both environmental and genetic factors are involved in the pathogenesis of ITP. IL-1 Ra polymorphisms were reported to be associated with susceptibility of a variety of autoimmune diseases.
This pilot case – control study was conducted at Hematology Oncology unit Children’s Hospital, Ain-Shams University in the period from October 2013 to January 2015, included 60 Egyptian children and adolescents from unrelated families, diagnosed with ITP who were regularly attending the clinic, aged 1-17years with mean of 9.2± 4.5. They were 37 female patients and 23 male patients. The study also included 50 age, sex and ethnically matched healthy controls.
We investigated the association between VNTRs of IL-1Ra Polymorphism and the susceptibility of ITP, The frequencies of the IL-1Ra polymorphic allele A2 as well as genotype A1A2 was significantly higher in cases of ITP compared to control.
The presence of allele A2 seems to increase 3.1 times the relative risk for disease development. Allele A1 may have a decreased risk for development of ITP. These findings suggested that IL-1Ra polymorphism may contribute to the susceptibility to ITP.
Comparison of genotypes and alleles regarding contributing factors associated with disease and demographic data were evaluated. There was no gender predominance among different genotypes. Also no significant difference was observed when the genotypes were compared regarding age of onset of the disease.
Other data
| Title | Association of different Variable Number of Tandem Repeats in Interleukin-1 Receptor Antagonist gene (IL-1 Ra VNTRs) with susceptibility to Childhood Immune Thrombocytopenia | Other Titles | العلاقة بين الاشكال الجينية المختلفة لمضاد مستقبلة الانترلوكين -1 والقابلية للأصابة بمرض نقص الصفيحات الدموية المناعي في الاطفال | Authors | Omnia Mohammed Abdel Aziz Borham | Issue Date | 2015 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.