SERUM LEPTIN STATUS IN FIBROID UTERUS BEFORE AND AFTER Surgical HYSTERECTOMY
Hala Ahmed Hassan Hamed;
Abstract
SUMMARY AND CONCLUSION
U
terine leiomyoma are the most common pelvic tumors leading to hysterectomy and have been identified as one of the leading causes of hospitalization for gynecological disorders and hysterectomy. Leptin is one of the most important adipose-derived hormones, encoded by the ob gene and appears to play an important role in energy expenditure, neuroendocrine- reproductive systems, and immune response. Dietary fat intake, high body mass index (BMI), estrogen, and progesterone are well-known risk factors for myoma uteri that may affect serum leptin levels.
These considerations led us to investigate possible relationship between uterine leiomyoma and serum leptin levels, by comparing serum leptin levels between women with uterine leiomyoma and women without leiomyoma, and then investigate the effects of hysterectomy on serum leptin levels.
The current study was carried out on sixty-seven women presented to outpatient clinic of gynecology at Ain Shams University Hospitals. Thirty patients with uterine leiomyoma (their ages ranged from 38-53 years with a mean of 46.4 ± 3.8 years) and thirty normal women (their ages between 35-53 years with a mean of 43.3 ± 4.8).
All the patients were subjected to complete history, clinical examination and laboratory investigations including: age, height, weight, BMI and estimation of leptin levels before and after surgery and in control group.
The obtained data revealed:
Significant relations (p value< 0.001) were found on comparing Leptin levels between myoma (before and after surgery) and control group. The same was observed for control and myoma after surgery, while non- significant differences were found on analyzing myoma before surgery and control group (p > 0.05).
A highly significant differences (p <0.01) was obtained on comparing leptin levels before and after surgery. Postoperative serum leptin levels were decreased than preoperative leptin levels (3.95 ± 1.911 ng/mL vs. 6.83 ± 3.86 ng/mL).
A non-significant correlation (p > 0.05) was observed between serum leptin levels and BMI in studied group (before surgery) and control group.
A highly significant difference (p <0.01) was observed between BMI and studied group (after surgery) and control group.
On conclusion: serum leptin levels were more decreased in women with uterine leiomyoma after hysterectomy. It seems that lower serum leptin levels may be related to resection of leiomyoma.
In conclusion; further investigation is needed for clinical use of serum leptin levels as a serum marker after conservative treatment of uterine leiomyoma.
U
terine leiomyoma are the most common pelvic tumors leading to hysterectomy and have been identified as one of the leading causes of hospitalization for gynecological disorders and hysterectomy. Leptin is one of the most important adipose-derived hormones, encoded by the ob gene and appears to play an important role in energy expenditure, neuroendocrine- reproductive systems, and immune response. Dietary fat intake, high body mass index (BMI), estrogen, and progesterone are well-known risk factors for myoma uteri that may affect serum leptin levels.
These considerations led us to investigate possible relationship between uterine leiomyoma and serum leptin levels, by comparing serum leptin levels between women with uterine leiomyoma and women without leiomyoma, and then investigate the effects of hysterectomy on serum leptin levels.
The current study was carried out on sixty-seven women presented to outpatient clinic of gynecology at Ain Shams University Hospitals. Thirty patients with uterine leiomyoma (their ages ranged from 38-53 years with a mean of 46.4 ± 3.8 years) and thirty normal women (their ages between 35-53 years with a mean of 43.3 ± 4.8).
All the patients were subjected to complete history, clinical examination and laboratory investigations including: age, height, weight, BMI and estimation of leptin levels before and after surgery and in control group.
The obtained data revealed:
Significant relations (p value< 0.001) were found on comparing Leptin levels between myoma (before and after surgery) and control group. The same was observed for control and myoma after surgery, while non- significant differences were found on analyzing myoma before surgery and control group (p > 0.05).
A highly significant differences (p <0.01) was obtained on comparing leptin levels before and after surgery. Postoperative serum leptin levels were decreased than preoperative leptin levels (3.95 ± 1.911 ng/mL vs. 6.83 ± 3.86 ng/mL).
A non-significant correlation (p > 0.05) was observed between serum leptin levels and BMI in studied group (before surgery) and control group.
A highly significant difference (p <0.01) was observed between BMI and studied group (after surgery) and control group.
On conclusion: serum leptin levels were more decreased in women with uterine leiomyoma after hysterectomy. It seems that lower serum leptin levels may be related to resection of leiomyoma.
In conclusion; further investigation is needed for clinical use of serum leptin levels as a serum marker after conservative treatment of uterine leiomyoma.
Other data
| Title | SERUM LEPTIN STATUS IN FIBROID UTERUS BEFORE AND AFTER Surgical HYSTERECTOMY | Other Titles | قياس مستوى الليبتن في الدم بالنسبة للورم الليفي الرحمي قبل وبعد استئصال الرحم | Authors | Hala Ahmed Hassan Hamed | Issue Date | 2014 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.