Histological study on the possible protective role of Moringa Oleifera leaves extract on Paracetamol induced liver damage in adult male albino rats

Abstract

Moringa oleifera is a tropical evergreen tree that has been used in human and animal nutrition. Extracts made from its leaves are widely used in homeopathic medicine in Asia. The leaves are known to be rich in antioxidant compounds. Recently, it has grown commercially and its therapeutic and protective effect has become a field of interest for many researchers. Although, considered safe over the counter analgesic, paracetamol is the most common cause of acute liver failure. Unintentional and chronic overdose accounts for 50% of paracetamol induced acute liver failure. Paracetamol hepatotoxicity is a significant public health concern that is largely attributed to paracetamol combined products prescribed by physicians. The main objective of this study was to investigate the possible protective role of Moringa oleifera leaves aqueous extract on paracetamol induced liver injury in adult male albino rats. Forty adult male albino rats were used in the current study. Animals were divided into four equal groups (ten rats each). Summary and Conclusions 145  Group I: control group.  Group II: rats were given 500 mg/kg body weight of Moringa oleifera leaves aqueous extract by nasogastric tube for 14 days.  Group III: rats were given water by nasogastric tube for 7 days. On the seventh day paracetamol was given by nasogastric tube in a dose of 400mg/kg body weight for another seven days.  Group IV: rats were given Moringa oleifera leaves aqueous extract (500mg/kg body weight) by nasogastric tube for 14 days and Paracetamol (400mg/kg body weight) by nasogastric tube on the seventh day for 7days. By the end of the experiment, rats were anaesthetized; blood was collected and liver samples were taken