Curcumin as a modulator of hepatic regeneration in a model of fatty liver in adult albino rat with reference to the role of the oval cell. Histological study.

Abstract

The present study evaluate the effect of curcumin on the regenerative capacity of the liver in experimentally induced NAFLD in adult male albino rats with reference to oval cells. Fifty adult male albino rats with average weight 200-250 gm. were used in this study. They were classified as follows: Group I: (control group) consisted of ten rats. It was subdivided into two subgroups. Subgroup Ia: (5 rats) they were given equivalent amount of normal saline via gastric tube for 4 weeks. Subgroup Ib: (5 rats) they were given equivalent amount of normal saline via gastric tube for 4 weeks and then they were left untreated for another 4 weeks. Group II (10 rats): Each rat was given equivalent amount of normal saline via gastric tube for 4 weeks then they received curcumin orally via gastric tube in a dose of 200mg/kg/day for 4 weeks. Group III (10 rats): Each rat received methionine orally via gastric tube in a dose of 1 gm/kg/day for 4 weeks to induce the model of NAFLD. Group IV (10 rats): Each rat received methionine for 4 weeks as in group III then they received curcumin for further 4 weeks in a dose of 200mg/kg/day. Group V (Recovery) (10 rats): Each rat received methionine for 4 weeks as in group III then they were left for recovery for 4 weeks.