Effect of low dose Asprin therapy on pregnancy rate in women undergoing in-vitro fertilization: A Randomised Controlled Trial

Abstract

Infertility defined by failure of to achieve a successful pregnancy after 12 months or more of appropriate, timed unprotected intercourse or therapeutic donor insemination. Infertility may be due to several problems medical, psychological and economic problems. Also male factor contribute by 45-50% of infertile couples. Unexplained infertility is present in approximately 10% of couples, with no easily identifiable cause of infertility. The principal treatments for unexplained infertility include: expectant management, clomiphene citrate, intrauterine insemination alone or with controlled ovarian stimulation and IVF. The clinical pregnancy rate among women undergoing fresh embryo transfer (ET) after IVF or intra cytoplasm sperm injection (ICSI) varies from 20% to 35% per transfer. Acetylsalicylic acid was synthesized in 1897 and was called aspirin. Aspirin inhibits the enzyme cyclooxygenase, thus avoiding prostaglandin (PG) synthesis (Rubinstein et al., 1999).