Study of CD184 (CXCR4) Expression in Chronic Lymphocytic Leukemia Patients
Nabila Reda Diab;
Abstract
Chronic lymphocytic leukemia (CLL) is a prevalent malignant tumor characterized by CLL cells homing in the bone marrow microenvironment.
CXCR4 (CD184) is a chemokine and chemokine receptor pair playing critical roles in tumor genesis. It is over expressed in many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgkin's lymphoma, and generally correlates with a poor prognosis (Li et al., 2016).
So, the present study aimed to determine clinical utility of CD184 in CLL patients in predicting disease outcome and planning treatment regimen. The study recruited 33 patients with CLL. They were subjected to careful history taking, thorough clinical and laboratory investigations including serological assessment of CD184.
Patients included in the present study comprised 21 males (63.6%) and 12 females (36.4%) with a mean age of 53.798.05 years. Documented patients’ history in the current study revealed that just 1 patient (3.0%) had hypertension while 5 patients (15.2%) had diabetes mellitus
On examination, 5 patients (15.2%) of our series had lymphadenopathy, 6 patients (18.2%) had hepato-splenomegaly and 19 patients (57.6%) had positive B symptoms.
Regarding laboratory data, patients included in the current study had hemoglobin level of 10.65 ± 3.04 gm/dl,
CXCR4 (CD184) is a chemokine and chemokine receptor pair playing critical roles in tumor genesis. It is over expressed in many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgkin's lymphoma, and generally correlates with a poor prognosis (Li et al., 2016).
So, the present study aimed to determine clinical utility of CD184 in CLL patients in predicting disease outcome and planning treatment regimen. The study recruited 33 patients with CLL. They were subjected to careful history taking, thorough clinical and laboratory investigations including serological assessment of CD184.
Patients included in the present study comprised 21 males (63.6%) and 12 females (36.4%) with a mean age of 53.798.05 years. Documented patients’ history in the current study revealed that just 1 patient (3.0%) had hypertension while 5 patients (15.2%) had diabetes mellitus
On examination, 5 patients (15.2%) of our series had lymphadenopathy, 6 patients (18.2%) had hepato-splenomegaly and 19 patients (57.6%) had positive B symptoms.
Regarding laboratory data, patients included in the current study had hemoglobin level of 10.65 ± 3.04 gm/dl,
Other data
| Title | Study of CD184 (CXCR4) Expression in Chronic Lymphocytic Leukemia Patients | Other Titles | دراسة تعبير معامل سى دى 184 (سى إكس سى آر 4) فى مرضى اللوكيميا الليمفاوية المزمنة | Authors | Nabila Reda Diab | Issue Date | 2017 |
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