The Effect of High Flux versus Low Flux Dialyzers on SERUM FGF-23 and ItsCardiovascular Implications in Prevalent Hemodialysis Patients

Abstract

Forty to fifty percent of patients with end-stage renal disease die because of cardiovascular disease (CVD). Altered calcium, phosphorus, parathyroid hormone (PTH), FGF-23, and vitamin D levels in ESRD induce mediators of bone-like metabolism and mineralization in the vascular tunica media. Fibroblast growth factor-23 is the main phosphaturic hormone and its levels start rising early in patients with chronic kidney disease and is implicated in cardiovascular and overall mortality of hemodialysis patients. FGF-23 increase precedes the rise of serum phosphate, thus, serum levels of FGF-23 might be a better prognostic biomarker than serum phosphate level for risk assessment in patient with CKD. Aim of this study was to compare between the effect