IN SITU HYBRIDIZATION FOR THE DETECTION OF TRISOMY 12 IN EGYPTIAN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA
NIHAL SALAH EL-DEEN EBRAHIM;
Abstract
hronic lymphocytic leukemia is a neollastic disease characterized by
Mthe accumulation of small mature appJaring lymphocytes in the blood, marrow and lymphoid tissues.
Chronic lymphocytic leukemia accounts for approximately 0.8 percent of all cancers and nearly 30 percent of allleJemias.
Generally, the neoplastic lymphocyteare of B-cell lineage. In less than 2 percent of cases, however, the neoplastic cells are ofT-cell origin.
ll;o mollgm '" H cell popolo
lymphocytes with regular nuclear and cyto lasmic outline and a clumped chromatin pattern. Membrane characteristics' of these cells include weak or negative surface immunoglobulin staining, CD5 positivity and FMC 7 negativity.
The cytogenetic abnormality most••commonly associated with• B-ceH ••
CLL is trisomy 12.
I
I
Because patients with trisomy 12 have
I
identification is important for treatment planni'ng.
Mthe accumulation of small mature appJaring lymphocytes in the blood, marrow and lymphoid tissues.
Chronic lymphocytic leukemia accounts for approximately 0.8 percent of all cancers and nearly 30 percent of allleJemias.
Generally, the neoplastic lymphocyteare of B-cell lineage. In less than 2 percent of cases, however, the neoplastic cells are ofT-cell origin.
ll;o mollgm '" H cell popolo
lymphocytes with regular nuclear and cyto lasmic outline and a clumped chromatin pattern. Membrane characteristics' of these cells include weak or negative surface immunoglobulin staining, CD5 positivity and FMC 7 negativity.
The cytogenetic abnormality most••commonly associated with• B-ceH ••
CLL is trisomy 12.
I
I
Because patients with trisomy 12 have
I
identification is important for treatment planni'ng.
Other data
| Title | IN SITU HYBRIDIZATION FOR THE DETECTION OF TRISOMY 12 IN EGYPTIAN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA | Other Titles | التهجين الاشعاعى الموضعى لتحديد الثلاثى فى الكروموزوم 12 فىحالات المرضى المصريين المصابين بمرض سرطان الدم الليمفاوى المزمن من النوع " بى " | Authors | NIHAL SALAH EL-DEEN EBRAHIM | Issue Date | 2001 |
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