Study on the effect of some antischistosomal drugs on experimental schistosomiasis
Maysa Ahmad Eraky;
Abstract
Schistosomiasis is a widespread disease. It affects more than 200 million people. Numerous approaches have been attempted to reduce the transmission of infection and the morbidity of the disease.
In control of schistosomiasis, the use of drugs that are safe and effective will remain the main tool until a successful vaccine is produced. Referring to the possibility of appearance of drug resistant parasites, specially with retreatment regimens in endemic areas, search for new schistosomicidals is essential.
Chemotherapeutics are sometimes used in combination to obtain a better therapeutic response than that obtained with each drug alone.
In the present work, the possible antischistosomal activity of myrrh, either alone or in combination with praziquantel on S. mansoni infected mice was studied.
A total number of 120 albino mice were divided into two major groups, the 1st group (80 mice were infected with S. mansoni cercariae through tail immersion method) and the 2nd group ( 40 mice were remain uninfected to be used as controls). 7 weeks after infection, mice were further classified into the following groups:
1- Non infected mice divided into 4 groups (each 10 mice): Group A: Constituted uninfected untreated control.
Group B: Treated with praziquantel alone in a dose of 500mg/kg body weight for 2 consecutive days.
Group C: Treated with myrrh alone in a dose of 500mg/kg body weight for 3 consecutive days.
Group D: Treated with both praziquantel and myrrh in reduced dose
( 1/3 curative dose).
In control of schistosomiasis, the use of drugs that are safe and effective will remain the main tool until a successful vaccine is produced. Referring to the possibility of appearance of drug resistant parasites, specially with retreatment regimens in endemic areas, search for new schistosomicidals is essential.
Chemotherapeutics are sometimes used in combination to obtain a better therapeutic response than that obtained with each drug alone.
In the present work, the possible antischistosomal activity of myrrh, either alone or in combination with praziquantel on S. mansoni infected mice was studied.
A total number of 120 albino mice were divided into two major groups, the 1st group (80 mice were infected with S. mansoni cercariae through tail immersion method) and the 2nd group ( 40 mice were remain uninfected to be used as controls). 7 weeks after infection, mice were further classified into the following groups:
1- Non infected mice divided into 4 groups (each 10 mice): Group A: Constituted uninfected untreated control.
Group B: Treated with praziquantel alone in a dose of 500mg/kg body weight for 2 consecutive days.
Group C: Treated with myrrh alone in a dose of 500mg/kg body weight for 3 consecutive days.
Group D: Treated with both praziquantel and myrrh in reduced dose
( 1/3 curative dose).
Other data
| Title | Study on the effect of some antischistosomal drugs on experimental schistosomiasis | Other Titles | دراسة عن تأثير بعض العقاقير في علاج مرض البلهارسيا في فئران التجارب | Authors | Maysa Ahmad Eraky | Issue Date | 2006 |
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