Assessment of Platelet Aggregation Function in Women with Unexplained Recurrent Miscarriage

Abstract

Background: Spontaneous abortion is the most common complication of pregnancy and is defined as the passage of a pregnancy prior to completion of 20 weeks gestation. Aim of the Work: The aim of this study is to evaluate the platelet aggregation function in women with unexplained recurrent miscarriage. Patients and Methods: his study was an observational case control study which included sixty non pregnant women recruited from Recurrent Miscarriage (RM) outpatient clinic (OPC) of Ain Shams University Maternity Hospital in the period from July 2016 till November 2016. Results: This study showed that there was statistical significant difference between both groups regarding aggregation response 0.309 mg/mL AA (P value = 0.009). However, there was no statistical significant difference regarding aggregation responses to other concentrations (2.5 mg/mL AA, 0.625 mg/mL AA, 0.17 mg/mL AA, 1.25mg/ml) (P value = 0.871, 0.533, 0.257, 0.704 respectively). Conclusion: It was concluded that patients with a history of unexplained recurrent first trimesteric pregnancy loss have greater platelet aggregation to submaximal dose of AA (0.309mg/ml) compared to control group. Recommendations: It is recommended to improve a prothrombotic state in unexplained recurrent miscarriage group by using antiplatelet drugs such as aspirin ± LMWH as an empirical rationale in management of this clinical condition. It has been thought that it is necessary to assess platelet aggregation function in patients with unexplained recurrent first trimestric miscarriage. Key words: spontaneous abortion, gestation, pregnancy, unexplained recurrent miscarriage, platelet aggregation