MANAGEMENT OF PATIENTS WITH HEMATOLOGICAL MALIGNANCY IN INTENSIVE CARE UNIT
Basem Gamal Fakhry;
Abstract
B
one marrow is one of the biggest organs in the human body. Its main function is hematopoiesis providing the circulating blood with optimal supply of platelets, leukocytes and erythrocytes for coagulation, immunity and oxygen transport. Histologically, bone marrow consists of cellular components, i.e. hematopoietic and fat cells, and supporting structures, i.e. osseous trabecule, reticular-adventitial cells, and vascular, lymphatic and nervous structures. With regard to physiology, bone marrow occurs in two forms: red marrow – hematopoietically active, and yellow marrow – inactive. The red bone marrow takes its name due to a large number of erythropoietic cells, whereas yellow bone marrow – due to predominance of fat cells. Moreover, the vascular net in the red bone marrow is much thicker than in the yellow bone marrow.
The most common reason for ICU transfer for all patients was respiratory compromise. The majority of all patients (68%) were eventually placed on ventilator support and approximately half required pressors. During the ICU course, 29 patients (32%) improved and subsequently resumed aggressive leukemia management, and 24 patients (27%) survived to be discharged from the hospital. The 2-, 6-, and 12-month overall survival was 24 (27%), 16 (18%), and 14 (16%), respectively.
one marrow is one of the biggest organs in the human body. Its main function is hematopoiesis providing the circulating blood with optimal supply of platelets, leukocytes and erythrocytes for coagulation, immunity and oxygen transport. Histologically, bone marrow consists of cellular components, i.e. hematopoietic and fat cells, and supporting structures, i.e. osseous trabecule, reticular-adventitial cells, and vascular, lymphatic and nervous structures. With regard to physiology, bone marrow occurs in two forms: red marrow – hematopoietically active, and yellow marrow – inactive. The red bone marrow takes its name due to a large number of erythropoietic cells, whereas yellow bone marrow – due to predominance of fat cells. Moreover, the vascular net in the red bone marrow is much thicker than in the yellow bone marrow.
The most common reason for ICU transfer for all patients was respiratory compromise. The majority of all patients (68%) were eventually placed on ventilator support and approximately half required pressors. During the ICU course, 29 patients (32%) improved and subsequently resumed aggressive leukemia management, and 24 patients (27%) survived to be discharged from the hospital. The 2-, 6-, and 12-month overall survival was 24 (27%), 16 (18%), and 14 (16%), respectively.
Other data
| Title | MANAGEMENT OF PATIENTS WITH HEMATOLOGICAL MALIGNANCY IN INTENSIVE CARE UNIT | Other Titles | رعاية مرضي اورام الدم الخبيثة بالعناية المركزة | Authors | Basem Gamal Fakhry | Issue Date | 2014 |
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