Evaluation of Domperidone Effect on ECG in Neonates
Mahmoud Ahmed Mohammed Abdelreheem;
Abstract
Gastroesophageal reflux is very common in childhood. If conservative procedures fail to relieve it, the use of a potent antiemetic agent that facilitates gastric motility and emptying, such as domperidone, is justified.
Domperidone is a peripheral, specific blocker of dopamine receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting; to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter) acts in the body.
The aim of the current study was to evaluate the effect of oral domperidone on QT interval and QTc in ECG in 100 neonates.
This study was conducted on 100 neonates (Group I: 50 preterm babies Group II: 50 fullterm babies both groups received domperidone for at least 2 days orally).
All neonates included in this study were subjected to:
Full history taking from their mothers laying stress on gestational age, parity and maternal medical history.
Clinical Examination was stressed on: APGAR score, Ballard score, sex, birth weight, and assessment of feeding tolerance.
With recording age of the baby at starting domperidone and duration of receiving it.
Babies Hemoglobin levels, hematocrit, TLC, PLT, serum electrolytes and CRP were measured before doing the ECG.
babies with any heart conduction abnormalities, receiving any drugs known to prolong QT interval or preexisting electrolyte disturbance, were excluded from the study.
Our results revealed that:
Domperidone didn't cause pathological long QT interval in full term and preterm neonates and there was no significant difference between both groups.
There was no significant difference between full term and preterm groups in levels of hemoglobin, hematocrit, TLC, PLT, serum electrolytes and CRP.
Also, we didn’t find significant difference between both groups as regards gender.
Domperidone is a peripheral, specific blocker of dopamine receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting; to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter) acts in the body.
The aim of the current study was to evaluate the effect of oral domperidone on QT interval and QTc in ECG in 100 neonates.
This study was conducted on 100 neonates (Group I: 50 preterm babies Group II: 50 fullterm babies both groups received domperidone for at least 2 days orally).
All neonates included in this study were subjected to:
Full history taking from their mothers laying stress on gestational age, parity and maternal medical history.
Clinical Examination was stressed on: APGAR score, Ballard score, sex, birth weight, and assessment of feeding tolerance.
With recording age of the baby at starting domperidone and duration of receiving it.
Babies Hemoglobin levels, hematocrit, TLC, PLT, serum electrolytes and CRP were measured before doing the ECG.
babies with any heart conduction abnormalities, receiving any drugs known to prolong QT interval or preexisting electrolyte disturbance, were excluded from the study.
Our results revealed that:
Domperidone didn't cause pathological long QT interval in full term and preterm neonates and there was no significant difference between both groups.
There was no significant difference between full term and preterm groups in levels of hemoglobin, hematocrit, TLC, PLT, serum electrolytes and CRP.
Also, we didn’t find significant difference between both groups as regards gender.
Other data
| Title | Evaluation of Domperidone Effect on ECG in Neonates | Other Titles | تقييم تأثير عقار الدومبيريدون على رسم القلب في الأطفال حديثي الولادة | Authors | Mahmoud Ahmed Mohammed Abdelreheem | Issue Date | 2015 |
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