Phenotypic and Genotypic detection of Methicillin-Resistant Staphylococci carrying the mecC gene
Hagar Mohamed Thabit Mohamed;
Abstract
SUMMARY
M
RSA is one of the most important pathogens causing a wide range of infections among not only hospitalized patients, but also in the community, with limited choice of antibiotics, making it's accurate and rapid diagnosis so crucial.
In 2011, a new mecA gene homologue, mecC gene, has emerged. It’s coding for a new Penicillin Binding Protein (PBP2c) which is only 69% identical to PBP2a at the DNA level and 63% on the protein level giving negative results when tested for MRSA using the latex agglutination test or the PCR designed for the detection of mecA gene and also functionally distinct from it making the screening for MRSA using the oxacillin disc by the DD method less reliable. That creates a challenge in the diagnosis of MRSA.
The prevalence of mecC-encoded MRSA vary between different countries with a tendency to increase in some of them and was linked to zoonotic transmition from Livestock.
M
RSA is one of the most important pathogens causing a wide range of infections among not only hospitalized patients, but also in the community, with limited choice of antibiotics, making it's accurate and rapid diagnosis so crucial.
In 2011, a new mecA gene homologue, mecC gene, has emerged. It’s coding for a new Penicillin Binding Protein (PBP2c) which is only 69% identical to PBP2a at the DNA level and 63% on the protein level giving negative results when tested for MRSA using the latex agglutination test or the PCR designed for the detection of mecA gene and also functionally distinct from it making the screening for MRSA using the oxacillin disc by the DD method less reliable. That creates a challenge in the diagnosis of MRSA.
The prevalence of mecC-encoded MRSA vary between different countries with a tendency to increase in some of them and was linked to zoonotic transmition from Livestock.
Other data
| Title | Phenotypic and Genotypic detection of Methicillin-Resistant Staphylococci carrying the mecC gene | Other Titles | التحديد المظهري والجيني للمكورات العنقودية المقاومة للميثيسلين والحاملة للميك سي جين | Authors | Hagar Mohamed Thabit Mohamed | Issue Date | 2017 |
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