IN VITRO FERTILIZATION GLOBAL OVERVIEW
Waleed Mamdouh ELkhyat;
Abstract
Our Knowledge of reproductive medicine has expanded rapidly since the birth of Louise Brown, the first baby to be conceived by in vitro fertilization, which was performed by Professors Steptoe and Edwards in Bournhall, England, in 1987.
Hardly a year goes without th.e development of a new modification of an existing method of assisted reproduction.
As controlled ovarian hyperstimulation is used in all methods of assisted reproduction, this work-essay begins with it in chapter 1.
The aims of ovarian hyperstimulation is to :
1- Promote the development of a relatively synchronous cohort of follicles; thus facilitating appropriate timing of human chorionic gonadotropin (hCG) administration and oocyte retrieval.
2- Collect multiple, mature oocytes that have the capacity to fertilize, cleave and initiate a viable pregnancy.
3- Achieve endometrial development that will support embryonic implantation and growth.
4- Minimize the cycle cancellation rate.
5- Maximize cost efficiency of medications and monitoring.
Several drugs are used to hyperstimulate the ovaries :
Clomiphene citrate (CC) was the first drug used for controlled ovarian hyperstimulation and although there is a lower pregnancy rate noticed in IVF when using CC alone as stimulation protocol , probably due to the lower mean number of oocytes and , as a consequence, less embryos placed into the utrine cavity. here and there some centers still use the CC protocol in thdr IVF program mainly because of its low cost.
Hardly a year goes without th.e development of a new modification of an existing method of assisted reproduction.
As controlled ovarian hyperstimulation is used in all methods of assisted reproduction, this work-essay begins with it in chapter 1.
The aims of ovarian hyperstimulation is to :
1- Promote the development of a relatively synchronous cohort of follicles; thus facilitating appropriate timing of human chorionic gonadotropin (hCG) administration and oocyte retrieval.
2- Collect multiple, mature oocytes that have the capacity to fertilize, cleave and initiate a viable pregnancy.
3- Achieve endometrial development that will support embryonic implantation and growth.
4- Minimize the cycle cancellation rate.
5- Maximize cost efficiency of medications and monitoring.
Several drugs are used to hyperstimulate the ovaries :
Clomiphene citrate (CC) was the first drug used for controlled ovarian hyperstimulation and although there is a lower pregnancy rate noticed in IVF when using CC alone as stimulation protocol , probably due to the lower mean number of oocytes and , as a consequence, less embryos placed into the utrine cavity. here and there some centers still use the CC protocol in thdr IVF program mainly because of its low cost.
Other data
| Title | IN VITRO FERTILIZATION GLOBAL OVERVIEW | Other Titles | اطفال الانابيب نظرة شمولية بين الحاضر والمستقبل | Authors | Waleed Mamdouh ELkhyat | Issue Date | 2001 |
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