Biochemical Evaluation Of The Role Of Ergocalciferol (Vitamin D2), Cholecalciferol (Vitamin D3), Osteocalcin And Parathyroid Hormone In Pathogenesis Of Liver Cirrhosis In Egyptian Patients

Abstract

In the present study we measured serum levels of osteocalcin, vitamin D2 , vitamin D3, parathyroid hormone, calcium, phosphorus, albumin and total protein as well as liver function tests, in 60 cirrhotic men [subgroup (1): 20 patient of liver cirrhosis with hepatitis; subgroup (2): 20 patient of liver cirrhosis with bilharziasis; subgroup (3): 20 patient of liver cirrhosis with both hepatitis and bilharziasis] and 20 healthy controls. In all patient subgroups the mean serum level of vitamin D2, vitamin D3, osteocalcin, calcium, Phosphorus, albumin and total protein were significantly decreased; while the mean serum level of parathyroid hormone concentration was significantly increased. In conclusion, patients with liver cirrhosis usually associated with abnormality in calcium metabolism. Thus this disturbance seems to reflect diminished