Autologous Bone Marrow-derived Mesenchymal Stem Cells versus Tension-free Vaginal Tape for Treatment of Female Stress Urinary Incontinence

Abstract

ABSTRACT: Background: Urinary incontinence is a significant health problem with considerable social and economic impact affecting over 200 million people worldwide. What further complicates the situation is that it represents a social stigma; so many women don’t seek medical evaluation, so the condition is under diagnosed & underreported. Stress urinary incontinence (SUI) is the most common type in women (especially in young women). Different treatment modalities are available for stress incontinence in women, however; they remain unable to target the fundamental mechanisms of injury or etiology of disease. Preliminary studies using stem cells aim at achieving a stronger urethral sphincter, as they have the ability to multiply & differentiate regenerating the urethral sphincter. Aim of the study: To compare the efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) periurethral injection to that of surgery- tension free vaginal tape (TVT) in treatment of female stress urinary incontinence.