The western - style diet: a major risk factor for kidney functions in rats.

Abstract

The Western Style Diet (WSD); called the meat-sweet diet or standard American diet, is characterized by an over availability of food, with high intakes of high-fat foods, high-sugar desserts and drinks, as well as high intakes of red meat, refined grains, WSD underlies the epidemic growing of obesity in the United States and throughout the world. It has been recognized as the major contributor to metabolic disturbances, hypertension, and cardiovascular diseases. Also, it has been associated with an increased incidence of chronic kidney disease CKD. A combination of dietary factors contributes to the impairment of renal vascularization, steatosis, inflammation, hypertension, and impaired renal hormonal regulation. It is thought to be contributed to the increasing incidence of several chronic illnesses including cancer (especially colon and liver), non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) and osteoporosis. The main objective of this study was to:1-To examine the effect of high fat diet and high fat high fructose diet on lipid metabolism in mice and uninephrectomized rats compared to low fat group. 2-To examine the effect of high fat diet and high fat high