Association between Mean Platelet Volume and Unexplained Recurrent Miscarriage

Abstract

Recurrent miscarriage is an important health problem, defined as the loss of two or more subsequent pregnancies, which affects 1-2% of reproductive-age women. Its etiology is blamed on genetic, endocrine, infectious, anatomic, thrombophilic and immunological reasons. In spite of the increase in our knowledge about implantation and early pregnancy, the causes of 50% of repeated pregnancy losses are unknown. The haemostatic system plays an important role in the successful completion of implantation and placentation. Platelets play an important role in the pathogenesis of vascular diseases. Mean platelet volume (MPV) is aphysiological variables with haemostatic importance. The MPV test is an indicator of platelet size. Increased MPV indicates that platelet diameters are greater. An increase in MPV shows that new platelet synthesis in bone marrow has increased. Thus bigger, younger and more functional platelets are produced and MPV increases. MPV tests are generally requested for differential diagnosis of thrombocytopenia. Since increased MPV levels are generally considered as a vascular risk factor, suggested the