Expression Of Steroid Sulfatase and Aromatase mRNA in breast cancer and Its clinical Significance

Ranya Abdel-Hadi Abdel-Aziz Tammam;

Abstract


Breast carcmoma is one of the most common malignancies in women worldwide. Estrogens play an important role in the development of hormone-dependent breast cancer, and estrogen receptor status is well known to affect the prognosis of patients with breast neoplasm (Suzoki et a/., 2003). More than two-thirds of breast cancers occur in post­ menopausal women, and depend on estrogens for their proliferation and survival (Nakata eta/, 2003). Tissue concentrations of estradiol in breast carcinomas are 10 times higher than the levels found in plasma, suggesting that estrogens in human breast cancer tissues may be produced in situ from circulating biologically inactive precursors (Suzoki et a/.,
2003).

In postmenopausal women, in whom ovar1an function has decreased, the peripheral metabolism and biosynthesis of estrogens via estrogen-metabolizing enzymes (EMEs) are important. EMEs include (aromatase, steroid sulfatase (STS), estrogen sulfotransferase (EST) and
17-hydroxysteroid dehydrogenase type-1 (HSD-1) (Honma eta/., 2006).

Aromatase converts circulating androgens from the adrenal gland or ovary into estrogens, androstenedione into estrone (E l) or testosterone into 17-estradiol (E2). STS hydrolyzes biologically inactive estrogen sulfates to produce active estrogens, whereas EST sulfonates estrogens to produce estrogen sulfates and HSD-1 catalyzes the reduction of a biologically weak estrogen, El, to the most potent estrogen, E2, (Honma eta/., 2006).


Two main pathways are involved in the formation of estrogens, the sulfatase pathway which transforms ElS into El, and the aromatase pathway which converts androgens into estrogens. Comparative studies


Other data

Title Expression Of Steroid Sulfatase and Aromatase mRNA in breast cancer and Its clinical Significance
Other Titles دراسة درجة التعبير عن السلفاتيز والاروماتيز في سرطان الثدي ودلالته الاكلينيكية
Authors Ranya Abdel-Hadi Abdel-Aziz Tammam
Issue Date 2006

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