IMMUNOHISTOCHEMICAL STUDY FOR EVALUATION OF TISSUE INTERCELLULAR ADHESION MOLECULE IN VITILIGO
SANAA MOUSTAFA ABD-ELMEGEED;
Abstract
Vitiligo is a relatively common acquired depigmenting disorder that affects at least 1o/o of population. There are various hypothesis for its pathogenesis, the most accepted theories include autoimmune, melanocyte self destruction and neurogenic one.
Intercellular adhesion molecule-1 (ICAM-1) is the most extensively studied molecule of immunoglobulin-supergene family, the large family of CAMs. ICAM-1 is expressed on keratinocytes in benign inflammatory lesions such as allergic eczema, urticaria, bullous diseases ... etc.
The aim of this work is to study the ICAM-1 expression in vitiligo lesions before and after topical psoralen therapy was studied.
This work was performed in the out-patient clinic, Dermatology and Venereology Department, Tanta University Hospital on 25 subjects:
20 vitiligo patients (10 males and 10 females) and 5 control. They were classified into three groups:
Group A: Stable vitiligo: included 10 patients With stable skin lesions. The duration ranged from 2 - 7 years.
Group B: Active vitiligo: included 10 patients With a duration ranging
from one month to one year With fresh lesions still appearing.
Intercellular adhesion molecule-1 (ICAM-1) is the most extensively studied molecule of immunoglobulin-supergene family, the large family of CAMs. ICAM-1 is expressed on keratinocytes in benign inflammatory lesions such as allergic eczema, urticaria, bullous diseases ... etc.
The aim of this work is to study the ICAM-1 expression in vitiligo lesions before and after topical psoralen therapy was studied.
This work was performed in the out-patient clinic, Dermatology and Venereology Department, Tanta University Hospital on 25 subjects:
20 vitiligo patients (10 males and 10 females) and 5 control. They were classified into three groups:
Group A: Stable vitiligo: included 10 patients With stable skin lesions. The duration ranged from 2 - 7 years.
Group B: Active vitiligo: included 10 patients With a duration ranging
from one month to one year With fresh lesions still appearing.
Other data
| Title | IMMUNOHISTOCHEMICAL STUDY FOR EVALUATION OF TISSUE INTERCELLULAR ADHESION MOLECULE IN VITILIGO | Other Titles | دراسة هستوكيميائية مناعية لتقييم جزئ التماسك بين الخلوى النسيجى فى مرضى البهاق | Authors | SANAA MOUSTAFA ABD-ELMEGEED | Issue Date | 1999 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B10966.pdf | 423.7 kB | Adobe PDF | View/Open |
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