Effect of Exercise Training on NT-Pro-BNP Plasma Levels in Patients with Left Ventricular Systolic Dysfunction after Anterior ST Elevation Myocardial Infarction

Abstract

SUMMARY his study was done to identify the Effect of exercise training on NT-PRO-BNP biochemical marker and Echocardiography Determinants in Patients with LV Systolic Dysfunction. In this study we included 40 patients of all age groups and of both sexes and was divided into two groups, each composed of 20 patients: Group A: that enrolled in a 3-month exercise-based cardiac rehabilitation (CR) program and Group B: the rest of patients who cannot comply to our program and these patients were discharged home with generic instructions to continue physical activity. All of them were recruited during the period between January 2015 to December 2015 for cardiac rehabilitation program with LV systolic dysfunction (LVEF<30-45%), and they were on optimal medical treatment for heart failure including diuretics and maximal tolerable doses of RAAS inhibitors (ACEI, ARBs and aldosterone antagonists) and BB according to recommendations of guidelines for treatment of systolic HF. All patients had full history and thorough physical examination, BNP, 12 lead surface ECG, echocardiography was done before and after recruitment in a 3 months exercise training program. Our study showed statistically significant improvement in functional capacity, exercise tolerance, Ejection fraction and T Summary 88 statistically significant reduction in heart rate compared to control group. Although BNP level was significantly reduced in both groups but the percent of change showed significant reduction in BNP level in patients group compared to control group. These findings were consistent with most of the previous studies in the same field. So, the present study found that involvement of patients in cardiac rehabilitation program improves their cardiovascular risk factors, functional capacity and Health related quality of life through optimization of medical treatment, risk factor control, prescribed exercise training, physical activity and motivation and it should be implemented in routine management of these patients and supported by the government.