Estradiol Pretreatment with Misoprostol in second Trimesteric Miscarriage A Prospective, Double-blind, Randomized Clinical Trial

Abstract

Miscarriage is the most common complications of pregnancy, occurring in 10 – 20% of clinically recognized pregnancies. Methods for induction of miscarriage can be surgical in form of vacuum aspiration, dilatation and curettage, and hysterotomy. Or pharmacological methods include prostaglandins, mifepristone and oxytocin. Misoprostol is a prostaglandin E1 analogue, has been shown to have both safety and efficacy for induction of abortion. In most trials vaginal route has been chosen, because this route has been most successful for other prostaglandins and because misoprostol has far longer half-life when administered vaginally than orally. With the ever increasing concentration of estrogen in the maternal circulation leading to term pregnancy, the belief that this could be a trigger for the onset of labor led to studies exploring estrogens for induction of miscarriage.