The impact of the use of plants Stevia on laboratory rats induced diabetic

Abstract

Diabetes prevalence was 20.0% in urban Egypt. There are new trend to use traditional natural medicines mainly originated in herbs, which is showing a bright future in the therapy of diabetes mellitus (DM) and its complications. Accordingly, this study aimed to study the effect of different doses of Stevia rebaudiana plants on blood glucose, lipid profile and kidney functions level in induced diabetic rats. The results indicated that, after six weeks of injection with alloxan diabetic rats treated with 7.5% dose of stevia tended to have blood sugar close to healthy group. Using the three levels from stevea 2.5%, 5% and 7.5% separately in treated diabetic rats led to significant decreases in serum triglycerides, as compared to the positive control group. The high level from stevia induced significant decrease in serum triglycerides and cholesterol in diabetic groups, as compared to the treated groups with 2.5% and 5% levels from those materials. high-density lipoprotein of hyperglycemic groups which treated with high level from stevea increased significantly at p<0.05, as compared to hyperglycemic groups which treated with 5% levels. Three levels from stevia -decreased serum LDL-c in rats suffering from hyperglycemia, as compared to positive control group. All treated groups with different tested diets produced an improvement in serum urea nitrogen and creatinine levels, as compared to positive control group. Dose of 7.5% of stevia have therapeutic effect. They possess hypolipidemic and hypoglycemic properties. Keywords: Diabetes- Stevia rebaudiana- kidney functions-liver function- lipid profile