EXPRESSION OF 8CL2 AND P53 IN KAPOSI'S SARCOMA
Iman Abdel Latif Fadel;
Abstract
Kaposi's sarcoma (KS) is an angioproliferative disease that is characterized by proliferation of spindle-shaped cells predominantly of vascular endothelial cell origin, neoangiogenesis, inflammatory cell infiltration and edema. It occurs primarily in elderly males or as a late complication of immunosuppression in patients undergoing organ transplantation. It has been reported to be associated with AIDS. AIDS-KS has a more aggressive clinical course and occurs mostly in homosexual and bisexual men.
Many factors may contribute to the pathogenesis of KS; however, HIV-1infection appears to be of paramount importance. HIV-1 infection and/or other antigenic stimulation result in increased levels of inflammatory cytokines including tumor necrosis factor (TNF), interleukin (IL)-1, interferon-gamma (IFN gamma) and IL-6 in serum and cultured leukocytes from HIV-1
• infected individuals. These stimulate proliferation of spindle cells and induce functional changes in normal vascular cells, the progenitors of KS spindle cells.
Many factors may contribute to the pathogenesis of KS; however, HIV-1infection appears to be of paramount importance. HIV-1 infection and/or other antigenic stimulation result in increased levels of inflammatory cytokines including tumor necrosis factor (TNF), interleukin (IL)-1, interferon-gamma (IFN gamma) and IL-6 in serum and cultured leukocytes from HIV-1
• infected individuals. These stimulate proliferation of spindle cells and induce functional changes in normal vascular cells, the progenitors of KS spindle cells.
Other data
| Title | EXPRESSION OF 8CL2 AND P53 IN KAPOSI'S SARCOMA | Other Titles | ظهور البى سى ال 2 والبى 53 فى ورم كابوسى | Authors | Iman Abdel Latif Fadel | Issue Date | 2003 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.