Anti-Müllerian Hormone Levels in Girls and Adolescents with Turner Syndrome: Relation to Karyotype, Pubertal Development and Growth Hormone Therapy

Abstract

SUMMARY T urner syndrome (TS), in which there is loss of all or part of one sex chromosome occurs in one in 2500 born females and is associated with short stature, and ovarian failure with sexual infantilism and infertility. Serum AMH level is thought to be a predictor of the follicle reserve, with high AMH levels associated with high number of remaining ovarian follicles. The decline in serum AMH levels precedes the changes in traditional markers for ovarian reserve, such as FSH, inhibin B and E2. Assessment of serum AMH, also at a young age, is indicative of ongoing follicular development. AMH levels of TS patients are lower but to some level overlapping with normal measurements of healthy females. This cross sectional study was conducted on 50 patients with TS, whose ages ranged from 4.5 to 20 years, with a mean of 13.56±3.38 years; patients were collected by random sampling technique during the period from February 2013 to February 2014, from Nile Hospital, Egyptian Health Insurance. Patients were compared to 40 age - and sex- matched healthy subjects serving as controls who were collected from the pediatric outpatient clinic from the same hospital.