VAGINAL MISOPROSTOL COMPARED WITH ORAL MISOPROSTOL IN TERMINATION OF SECOND TRIMESTER PREGNANCY
Khalid AbdEl-Aziz Mohamed;
Abstract
INTRODUCTION: The need for safe methods of performing second trimester therapeutic pregnancy termination has increased recently and one of these methods is the use of prostaglandins. Misoprostol which is PGE 1 analogue offers a good, effective and safe method for induction of therapeutic second trimester pregnancy termination.
STUDY DESIGN: A prospective randomized clinical study was conducted in Department of Obstetrics and Gynecology in Benha University Hospital in Kalyobia Governorate during the period from September 2004 till September 2005 in which termination of pregnancy was attempted in 50 women.
AIM OF THE WORK: To compare the efficacy, side effects and acceptability of two different misoprostol regimens: vaginal or oral for induction of mid-trimester therapeutic abortion.
SUBJECTS AND METHODS: 50 women were included in this
study. After giving them an initial dose of 800g vaginally they were
divided into 2 groups, group I (oral group) and group II (vaginal group). Group I received 400 Lg misoprostol orally every 8 hours and group II were given the same dose vaginally every 8 hours. The protocol was followed for 48 hours after which further management was done.
WL- compared the two groups according to eflicacy and side effects.
RESULTS: Induction time and hospital stay were slightly shorter for the
oral group (13.5+5.014 hours) versus (17.4+7.2 hours) for the vaginal /
group, however the difference was not statistically significant (P>0.05),
side effects were similar for both groups.
CONCLUSIONS: After an initial 800 Lg dose of vaginalmisoprostol, a I
t \
regimen of 400g of oral misoprostol every 8 hours is as effective as
the same dose of vaginal misoprostol with no additional side effects, which provides a convenient alternative for second trimester
pregnancy termination.
STUDY DESIGN: A prospective randomized clinical study was conducted in Department of Obstetrics and Gynecology in Benha University Hospital in Kalyobia Governorate during the period from September 2004 till September 2005 in which termination of pregnancy was attempted in 50 women.
AIM OF THE WORK: To compare the efficacy, side effects and acceptability of two different misoprostol regimens: vaginal or oral for induction of mid-trimester therapeutic abortion.
SUBJECTS AND METHODS: 50 women were included in this
study. After giving them an initial dose of 800g vaginally they were
divided into 2 groups, group I (oral group) and group II (vaginal group). Group I received 400 Lg misoprostol orally every 8 hours and group II were given the same dose vaginally every 8 hours. The protocol was followed for 48 hours after which further management was done.
WL- compared the two groups according to eflicacy and side effects.
RESULTS: Induction time and hospital stay were slightly shorter for the
oral group (13.5+5.014 hours) versus (17.4+7.2 hours) for the vaginal /
group, however the difference was not statistically significant (P>0.05),
side effects were similar for both groups.
CONCLUSIONS: After an initial 800 Lg dose of vaginalmisoprostol, a I
t \
regimen of 400g of oral misoprostol every 8 hours is as effective as
the same dose of vaginal misoprostol with no additional side effects, which provides a convenient alternative for second trimester
pregnancy termination.
Other data
| Title | VAGINAL MISOPROSTOL COMPARED WITH ORAL MISOPROSTOL IN TERMINATION OF SECOND TRIMESTER PREGNANCY | Other Titles | مقارنة استخدام عقار الميزوبروستول عن طريق الفم أو المهبل في إنهاء الحمل في مرحلة الشهور الثلاثة الثانية من الحمل | Authors | Khalid AbdEl-Aziz Mohamed | Issue Date | 2006 |
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