EFFECT OF SILDENAFIL CITRATE ON TOTAL ANTIOXIDANT CAPACITY SERUM LEVELS IN PATIENTS WITH UNEXPLAINED RECURRENT MISCARRIAGES: A RANDOMIZED CLINICAL TRIAL

Abstract

he aim of the study is to measure the effect of oral sildenafil citrate 25 mg on serum levels of total antioxidant capacity in patients with unexplained recurrent miscarriages. This prospective case control study was conducted at Ain Shams University Maternity Hospital outpatient clinics. The study included 180 women who were divided into 2 groups: (group 1) which included 91 patients who took sildenafil citrate 25 mg orally, 4 times per day for 21 days (Sildenafil 25 mg tablet, EIPICO, Inc, Cairo, Egypt) and (group 2) which included 89 patients who took placebo orally, 4 times per day for 21 days. Our inclusion criteria was: age 18-35 years and ≥ 3 recurrent spontaneous abortions before the 24th week of gestation with no apparent cause for their previous losses and Three or more months have elapsed since the last abortion in Postmenstrual period and no other therapy allowed during our treatment course. Our exclusion criteria was: Concomitant use of organic nitrites, or nitrates, any severe hepatic, renal, or cardiovascular impairment, history of stroke or myocardial infarction or patients with retinitis pigmentosa. T Summary & conclusion 133