Comparison between Carbetocin and Oxytocin in Elective Caesarean Section with High Risk of Postpartum Hemorrhage: A Randomized Controlled Trial

Abstract

This randomized, double-blinded clinical study included 264 women (133 women received 100µg carbetocin IV and 131 women received 5 IU oxytocin IV). All women had high-risk for developing PPH; 7 women had macrosomicfetus, 110 women had multiple gestations, 55 had placenta previa, 9 women had polyhydramnios, 44 had past history of PPH and 32 women had uterine fibroid. Women with hypertension, preeclampsia, cardiac, renal or Liver diseases, epilepsy and history of hypersensitivity to carbetocin were excluded.All patients underwent elective cesarean section under general anaesthesia. Uterinetone was assessed at different time intervalson three-grade scale (Atony, Intermediate, Good) during CS, at the end of CS, 2 hours, 12 hours and 24 hours after delivery, the actual blood loss was calculated using the following formula:the estimated blood volume X difference between the initial hematocrit and the final hematocrit / the initial haematocrit and estimated blood volume equals booking weight (kg) X 85 (Shook et al., 2003).