Possible Protective Effect of Carnosine on Cadmium-Induced Renal Dysfunction in Old Rats

Abstract

Due to carnosine’s multifunctional properties, the present study was designed to study the effect of carnosine as potential antioxidant agent on cadmium–induced renal oxidative stress and lipid peroxidation. The present study was performed on 45 aged female Wistar rats, weighing at the start of the study between 280-380 g. Animals were randomly divided into the following groups: 1. Control group: (n=15 ) Rats in this group were injected intra-peritoneally (i.p) with normal saline, in volumes equivalent to those in which cadmium chloride (CdCl2) was dissolved, 6 days/week, for 2 weeks. 2. Cadmium group: (n=15 ) Rats in this group were injected i.p. with cadmium chloride (Nile Company. Egypt) in a dose of 2 mg /kg daily ,6 days / week for 2 weeks 3. Carnosine treated group: (n=15 ) Rats in this group received cadmium chloride in a dose of 2 mg/kg/day i.p. injection 1 hour after i.p. injection of carnosine in a dose of 10 mg /kg /day.