The Role of Antiovarian Autoantibodies in Polycystic Ovary Syndrome
Mary Maher Shoukry;
Abstract
SUMMARY AND CONCLUSION
P
olycystic ovary syndrome is the most common endocrine disorder in women of child-bearing age. It is typically identified during the early reproductive years or adolescence. Worldwide, PCOS affects 6–10% of women. The main underlying endocrinopathies related to PCOS are hyperandrogenism and impaired glucose tolerance secondary to insulin resistance. Also, Women with PCOS display abnormal patterns of gonadotropin pulsatility, which is characterised by excessive secretion of LH but normal secretion of follicle-stimulating hormone (FSH). This pattern of secretion gives rise to an abnormal circulating LH to FSH ratio in some patients.
Genetic, hormonal and Environmental factors play crucial role in the pathogenesis of PCOS. Autoimmunity has been proposed in the pathogenesis of PCOS since early 1990s as several authors have reported association between PCOS and certain autoimmune disorders, including autoimmune thyroiditis, chronic lymphocytic thyroiditis, diabetes mellitus, and even autoimmune oophoritis and premature ovarian failure. The link between PCOS and autoimmunity has been the question of recent studies and reviews.
P
olycystic ovary syndrome is the most common endocrine disorder in women of child-bearing age. It is typically identified during the early reproductive years or adolescence. Worldwide, PCOS affects 6–10% of women. The main underlying endocrinopathies related to PCOS are hyperandrogenism and impaired glucose tolerance secondary to insulin resistance. Also, Women with PCOS display abnormal patterns of gonadotropin pulsatility, which is characterised by excessive secretion of LH but normal secretion of follicle-stimulating hormone (FSH). This pattern of secretion gives rise to an abnormal circulating LH to FSH ratio in some patients.
Genetic, hormonal and Environmental factors play crucial role in the pathogenesis of PCOS. Autoimmunity has been proposed in the pathogenesis of PCOS since early 1990s as several authors have reported association between PCOS and certain autoimmune disorders, including autoimmune thyroiditis, chronic lymphocytic thyroiditis, diabetes mellitus, and even autoimmune oophoritis and premature ovarian failure. The link between PCOS and autoimmunity has been the question of recent studies and reviews.
Other data
| Title | The Role of Antiovarian Autoantibodies in Polycystic Ovary Syndrome | Other Titles | دورالأجسام الذاتية المضادة للمبيض في متلازمة المبيض المتعدد الكيسات | Authors | Mary Maher Shoukry | Issue Date | 2017 |
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