Serum level of Visfatin in psoriasis and its relation to disease severity
Waleed Mohamed Abd Elfattah;
Abstract
SUMMARY
P
soriasis is a chronic relapsing inflammatory skin disease mostly characterized by red, scaly, sharply demarcated, indurated plaques, present particularly over extensor surfaces and the scalp.
The pathogenesis of psoriasis involves an interaction between genetic, environmental and immunologic factors. Advances in the understanding of the role of inflammatory cells and mediators in the pathogenesis of psoriasis have shifted the clinical perspective on psoriasis from that of skin disorder to that of systemic inflammatory process that may increase the prevalence of other co-morbid conditions.
The most common form of the disease is chronic plaque psoriasis(psoriasis vulgaris), which manifests as plaques of red, scaly and well demarcated regions of inflamed skin.
Adipose tissue is an important endocrine organ secreting adipokines which have an important regulatory function throughout the body.
Visfatin is a 52-kDa protein(one of the adipokines) secreted primarily by visceral adipose tissue and various cells such as neutrophils,monocytes, macrophages as well as epithelial andendothelial cells might be a source of visfatin after inductionwith inflammatory stimuli.
P
soriasis is a chronic relapsing inflammatory skin disease mostly characterized by red, scaly, sharply demarcated, indurated plaques, present particularly over extensor surfaces and the scalp.
The pathogenesis of psoriasis involves an interaction between genetic, environmental and immunologic factors. Advances in the understanding of the role of inflammatory cells and mediators in the pathogenesis of psoriasis have shifted the clinical perspective on psoriasis from that of skin disorder to that of systemic inflammatory process that may increase the prevalence of other co-morbid conditions.
The most common form of the disease is chronic plaque psoriasis(psoriasis vulgaris), which manifests as plaques of red, scaly and well demarcated regions of inflamed skin.
Adipose tissue is an important endocrine organ secreting adipokines which have an important regulatory function throughout the body.
Visfatin is a 52-kDa protein(one of the adipokines) secreted primarily by visceral adipose tissue and various cells such as neutrophils,monocytes, macrophages as well as epithelial andendothelial cells might be a source of visfatin after inductionwith inflammatory stimuli.
Other data
| Title | Serum level of Visfatin in psoriasis and its relation to disease severity | Other Titles | مستوى فيسفاتين فى المصل فى الصدفية ومدى ارتباطه بشدة المرض | Authors | Waleed Mohamed Abd Elfattah | Issue Date | 2017 |
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