"Comparative Study between Plant extracts and metformin on weight reduction in obese rats"

Abstract

The worldwide obesity epidemic had produced profound effects on public health. Grains such as rice and oat may offer some protection against the early stage of obesity and the development of complications. The research aimed at comparative study between brown rice, germinated brown rice, and oat and metformin on overweight reduction in obese rats of lipid profiles (total cholesterol, triglycerides, low density lipoprotein (LDL-c), high density lipoprotein (HDLc) and very low density lipoprotein (VLDL-c)) and liver function (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) in rats. This work was carried out on 60 adult male white albino rats (Sprague-Dawley strain) randomly classified into ten groups. The results indicated that the statistical analysis referred that the positive control group was significantly increased in feed intake, triglycerides, HDL/LDL-cholesterol and VLDL-cholesterol comparing with group (3) (188.43 g and 98 g), (123.8 mg/dL and 117.3 mg/dL), (5.42 mg/dL and 0.439 mg/dL), (24.767 mg/dL and 23.467 mg/dL). On the other hand, group (6) in the relative weight heart, kidney and liver was significantly decreased comparing with positive control group (0.417 g and 0.517 g– 0.8 g and 1.15 g–3.51 g and 5.65 g). Data represented showed that the significant increase in positive control groups comparing with group (4) of total lipids and glucose (208 mg/dL and 193.3 mg/dL) and (97.5 mg/dL and 76.5 mg/dL), while the positive control group was significantly increased in total cholesterol, HDL-cholesterol, ALT and AST comparing with group (6) (84.333 mg/dL and 56.333 mg/dL), (18.5 mg/dL and 7.167 mg/dL), (23.16 U/L and 13.5 U/L), and (130.5 U/L and 48.7 U/L). Effect of feeding different diet on histopathological of experimental rat's liver of rat from group 2 showing fatty change of hepatocytes and group( 4) showing hydropic degeneration of hepatocytes. While group (8) showing fatty change of sporadic hepatocytes and also from group (10) showing slight hydropic degeneration of hepatocytes. Effect of feeding different diet on histopathological of experimental rats fats Adipose tissue of rat from group 2 showing large size adipocytes. Keywords: obesity, brown rice, germinated brown rice, oat, metformin, lipid profiles, and liver function